Top Papers Top 20 papers overall 1992-2002 Top Authors Top 20 overall 1992-2002 Top Institutions Top 20 overall 1992-2002 Top Nations Top 20 overall 1992-2002 Top Journals Top 20 overall 1992-2002 Time Series • 1 year • 5 year Field Distribution Field representation 1992-2002 Read interviews and first-person essays about people in a wide variety of fields, and information on journals in the topic of Alzheimer's Disease. August 2003 Neuroscience Letters July 2003 Rudolph E. Tanzi June 2003 Dennis Selkoe ADDITION OF DATA (August 13, 2007): A podcast from Dennis Selkoe has been added to this interview. Two formats available: mp3 | wma May 2003 Jonathan L. Haines April 2003 Dr. Warren Strittmatter Interview from incites.com

Alzheimer’s disease is brain disorder that causes severe dementia. It is mainly found in older people, appearing after age 60. According to the National Institutes of Health, approximately three percent of people aged 65-74 have Alzheimer’s disease. Special Topics has analyzed the literature published on this disease in the past decade. There are four main themes manifested in the top 20 papers from this time period. The first is most prevalent: intensive research into the structure and function of the various alleles of apolipoprotein-E, particularly the type 4 allele and its role in the pathogenesis of Alzheimer’s disease. Closely linked to apolipoprotein-E research is that on the amyloid peptides. The beta-amyloid peptide, which has been found in cerebrospinal fluid and other human biological fluids, has the potential to be used as a diagnostic test as well as a therapeutic strategy. Several cloning and genetic linkage studies are in the top 20 list as well, examining the potential susceptibility of specific gene loci for missense mutations which might result in Alzheimer’s disease. Clinical trials of high-dose tacrine, selegene, and alpha-tocopherol report promising results for slowing the progression of the disease and improving the quality of life in affected patients. One paper on the list discusses the potential role of estrogen in postmenopausal women for delaying onset of Alzheimer’s disease.

Methodology

To construct this database, papers were extracted based on a title word search and the supplied keywords for Alzheimer's Disease. The keywords used were as follows: Alzheimer*.

The baseline time span for this database is 1992-2002. The resulting database contained 19,057 papers; 29,502 authors; 79 countries; 1,296 journals; and 5,875 institutions.

Rankings

Once the database was in place, it was used to generate the lists of top 20 papers, authors, journals, institutions, and nations, covering a time span of 1992-2002.

The top 20 papers are ranked according to total cites. Rankings for author, journal, institution, and country are listed in three ways: according to total cites, total papers, and total cites/paper. The paper thresholds used to determine scientist, institution, country, and journal rankings according to total cites/paper were as follows: 29, 27, 35, and 44, respectively.

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