| The baseline time span for this database
is 1994-2004 (sixth bimonthly, an 11-year period). The resulting database contained
43,752 (10 years)
and 9,175 (2 years) papers;
82,748 authors; 119 countries; 1,744 journals; and 13,911 institutions. Read the methodology used to create this
special topic.
According to the National Cancer Institute, breast cancer is the
most common cancer in women, following skin cancer. In 2003, there
were an estimated 212,600 new cases of breast cancer in women, and
every year, approximately 1,300 men are diagnosed as well. Special
Topics first examined breast cancer research in 2001, and this month,
we revisit the topic to see what advances are now being cited.
The top 20 breast cancer papers from the past decade are dominated
by research related to the BRCA1 and BRCA2 cancer susceptibility
genes. In fact, the #1 paper from the past decade, "A strong
candidate for the breast and ovarian cancer susceptibility gene
BRCA1" (Miki, Y., et al., Science 266:66-71, 1994), has
been cited over 600 times more than the next-ranked paper, and has
given its authors a large boost in citations on our top 20 authors
list. Other topics found in the top 20 breast cancer papers over the
past decade include the use of tamoxifen in the NSABP trial and the
use of raloxifene in the MORE trial; the risk of breast cancer with
estrogens and progesterones; sentinel node biopsy vs. axillary
dissection; lymphatic mapping; sentinel lymphadenectomy; and the use
of postoperative radiotherapy in patients who have received adjuvant
chemotherapy.
Over the past two years, the top 20 breast cancer papers reflect
much of these same topics, but also contain the results of other major
clinical trials, such as the Million Women Study and the Women’s
Health Initiative. Studies on tamoxifen and raloxifene are joined by
studies on letrozole (with or without tamoxifen), as well as
paclitaxel and doxorubicin (given both singly and in conjunction).
Other topics include tumorigenic breast cancer cells, metastasis to
bone, and the role of gene expression in prediction of and response to
breast cancer. The results of a 20-year follow-up study on mammography
screening are also reported.
Methodology
To construct this database,
papers were extracted based on title-supplied keywords for breast
cancer. The keywords used were as follows:
breast cancer*
-or-
breast carcinoma*
-or-
breast neoplasm*
-or-
breast tumor*
-or-
BRCA*
The baseline time span for this database
is 1994-2004 (sixth bimonthly, an 11-year period). The resulting database contained
43,752 (10 years)
and 9,175 (2 years) papers; 82,748 authors; 119 countries; 1,744 journals; and
13,911 institutions.
Rankings
Once the database was in place,
it was used to generate the lists of top 20 papers (two- and ten-year
periods), authors, journals,
institutions, and nations, covering a time span of 1994-2004 (sixth bimonthly,
an 11-year period).
The top 20 papers are ranked
according to total cites. Rankings for author, journal, institution,
and country are listed in three ways: according to total cites, total
papers, and total cites/paper. The paper thresholds and corresponding
percentages used to determine
scientist, institution, country, and journal rankings according to
total cites/paper, and total papers respectively are as follows:
| Entity: |
Scientists |
Institutions |
Countries |
Journals |
| Thresholds: |
25 |
103 |
15 |
35 |
| Percentage: |
1% |
1% |
50% |
10% |
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