COX-2 inhibitors are the evolutionary endpoints (at least, so far)
of a development that began with aspirin a century ago, progressed to
non-steroidal anti-inflammatory drugs (NSAIDS), and then capitalized
on the realization that inhibition of the inducible COX-2 enzyme was
central to both the beneficial and toxic effects of these drugs.
ESI’s 10-year ranking of the hottest papers on COX-2 inhibition
is dominated by review articles on the biology, pharmacology, and
synthesis of the COX-2 inhibitors. The collection includes the early
trials of the safety and efficacy of celecoxib, and evaluations of the
role of COX-2 in colon cancer and the potential of COX-2 inhibition
for chemoprevention.
Over the past two years, the potential of COX-2 inhibition as a
cancer therapy takes over the dominant position in the field, and this
includes the single hottest paper, a review of NSAIDS and COX-2
inhibitors as anti-cancer agents. Another half-dozen articles in this
list discuss the role of COX-2 enzymes and the potential of COX-2
inhibition in colon and prostate cancer, as well as the significance
of COX-2 expression in breast cancer. Other prominent themes in the
top 20 are NSAIDS and COX-2 inhibitors in myocardial infarction, and
the efficacy and tolerability of COX-2 inhibition for the treatment of
arthritis.
Methodology
To construct this database,
papers were extracted based on title- and author-supplied keywords for
COX-2 Inhibitors. The keywords used were as follows:
COX-2 inhibit*
-or-
COX-II inhibit*
-or-
cyclooxygenase-2 inhibit*
-or-
cyclooxygenase-II inhibit*
The baseline time span for this database
is 1994-2004 (fifth bimonthly). The resulting database contained 3,805 (10 years)
and 2,193 (2 years) papers; 11,198 authors; 60 countries; 804 journals; and
2,092 institutions.
Rankings
Once the database was in place,
it was used to generate the lists of top 20 papers (two, and ten years
periods), authors, journals,
institutions, and nations, covering a time span of 1994-2004
(fifth
bimonthly).
The top 20 papers are ranked
according to total cites. Rankings for author, journal, institution,
and country are listed in three ways: according to total cites, total
papers, and total cites/paper. The paper thresholds and corresponding
percentages used to determine
scientist, institution, country, and journal rankings according to
total cites/paper, and total papers respectively are as follows:
| Entity: |
Scientists |
Institutions |
Countries |
Journals |
| Thresholds: |
10 |
26 |
10 |
12 |
| Percentage: |
1% |
1% |
50% |
10% |
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