Label: OSHIMA-1996
Title: SUPPRESSION OF INTESTINAL POLYPOSIS IN APC(DELTA 716) KNOCKOUT MICE BY INHIBITION OF CYCLOOXYGENASE 2 (COX-2)
Journal: CELL, vol. 87, p. 803-809, 1996
Citations: 1115
Authors: OSHIMA, M; DINCHUK, JE; KARGMAN, SL; OSHIMA, H; HANCOCK, B; KWONG, E; TRZASKOS, JM; EVANS, JF; TAKETO, MM
Addresses:
BANYU TSUKUBA RES INST MERCK, TSUKUBA, IBARAKI 30033, JAPAN
DUPONT MERCK PHARMACEUT CO, , WILMINGTON, USA
MERCK & CO INC, POINTE CLAIRE, PQ H9R 4P8, CANADA
UNIV TOKYO, FAC PHARMACEUT SCI, TOKYO 113, JAPAN

Label: TSUJII-1998
Title: CYCLOOXYGENASE REGULATES ANGIOGENESIS INDUCED BY COLON CANCER CELLS
Journal: CELL, vol. 93, p. 705-716, 1998
Citations: 885
Authors: TSUJII, M; KAWANO, S; TSUJI, S; SAWAOKA, H; HORI, M; DUBOIS, RN
Addresses:
VANDERBILT UNIV, Med Ctr, Nashville, USA
VANDERBILT UNIV, Med Ctr, Nashville, USA
VANDERBILT UNIV, Med Ctr, Nashville, USA
OSAKA UNIV, Sch Med, Osaka 5650871, Japan

Label: MASFERRER-1994
Title: SELECTIVE-INHIBITION OF INDUCIBLE CYCLOOXYGENASE-2 IN-VIVO IS ANTIINFLAMMATORY AND NONULCEROGENIC
Journal: PROC NAT ACAD SCI USA, vol. 91, p. 3228-3232, 1994
Citations: 817
Authors: MASFERRER, JL; ZWEIFEL, BS; MANNING, PT; HAUSER, SD; LEAHY, KM; SMITH, WG; ISAKSON, PC; SEIBERT, K
Addresses:
SEARLE & CO, SEARLE INFLAMMATORY DIS RES, ST LOUIS, USA

Label: VANE-1998
Title: CYCLOOXYGENASES 1 AND 2
Journal: ANNU REV PHARMACOL TOXICOL, vol. 38, p. 97-120, 1998
Citations: 736
Authors: VANE, JR; BAKHLE, YS; BOTTING, RM
Addresses:
UNIV LONDON QUEEN MARY & WESTFIELD COLL, St Bartholomews & Royal London Sch Med & Dent, London EC1M 6BQ, England
UNIV LONDON QUEEN MARY & WESTFIELD COLL, St Bartholomews & Royal London Sch Med & Dent, London EC1M 6BQ, England

Label: STEINBACH-2000
Title: THE EFFECT OF CELECOXIB, A CYCLOOXYGENASE-2 INHIBITOR, IN FAMILIAL ADENOMATOUS POLYPOSIS
Journal: N ENGL J MED, vol. 342, p. 1946-1952, 2000
Citations: 600
Authors: STEINBACH, G; LYNCH, PM; PHILLIPS, RKS; WALLACE, MH; HAWK, E; GORDON, GB; WAKABAYASHI, N; SAUNDERS, B; SHEN, Y; FUJIMURA, T; SU, LK; LEVIN, B; GODIO, L; PATTERSON, S; RODRIGUEZ-BIGAS, MA; JESTER, SL; KING, KL; SCHUMACHER, M; ABBRUZZESE, J; DUBOIS, RN; HITTELMAN, WN; ZIMMERMAN, S; SHERMAN, JW; KELLOFF, G
Addresses:
UNIV TEXAS, MD Anderson Canc Ctr, Houston, USA
UNIV TEXAS, MD Anderson Canc Ctr, Houston, USA
ST MARKS HOSP, Imperial Canc Res Fund, London EC1V 2PS, England
NCI, , Bethesda, USA
SEARLE & CO, , Skokie, USA

Label: KAWAMORI-1998
Title: CHEMOPREVENTIVE ACTIVITY OF CELECOXIB, A SPECIFIC CYCLOOXYGENASE-2 INHIBITOR, AGAINST COLON CARCINOGENESIS
Journal: CANCER RES, vol. 58, p. 409-412, 1998
Citations: 466
Authors: KAWAMORI, T; RAO, CV; SEIBERT, K; REDDY, BS
Addresses:
AMER HLTH FDN, Div Nutr Carcinogenesis, Valhalla, USA
AMER HLTH FDN, Div Nutr Carcinogenesis, Valhalla, USA
SEARLE & CO, , St Louis, USA

Label: SHENG-1998
Title: MODULATION OF APOPTOSIS AND BCL-2 EXPRESSION BY PROSTAGLANDIN E-2 IN HUMAN COLON CANCER CELLS
Journal: CANCER RES, vol. 58, p. 362-366, 1998
Citations: 418
Authors: SHENG, HM; SHAO, JY; MORROW, JD; BEAUCHAMP, RD; DUBOIS, RN
Addresses:
VANDERBILT UNIV, Med Ctr, Nashville, USA
VANDERBILT UNIV, Med Ctr, Nashville, USA
VANDERBILT UNIV, Med Ctr, Nashville, USA
VANDERBILT UNIV, Med Ctr, Nashville, USA
VANDERBILT UNIV, Med Ctr, Nashville, USA
VET ADM MED CTR, , Nashville, USA

Label: PENNING-1997
Title: SYNTHESIS AND BIOLOGICAL EVALUATION OF THE 1,5-DIARYLPYRAZOLE CLASS OF CYCLOOXYGENASE-2 INHIBITORS: IDENTIFICATION OF 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE (SC-58635, CELECOXIB)
Journal: J MED CHEM, vol. 40, p. 1347-1365, 1997
Citations: 406
Authors: PENNING, TD; TALLEY, JJ; BERTENSHAW, SR; CARTER, JS; COLLINS, PW; DOCTER, S; GRANETO, MJ; LEE, LF; MALECHA, JW; MIYASHIRO, JM; ROGERS, RS; ROGIER, DJ; YU, SS; ANDERSON, GD; BURTON, EG; COGBURN, JN; GREGORY, SA; KOBOLDT, CM; PERKINS, WE; SEIBERT, K; VEENHUIZEN, AW; ZHANG, YY; ISAKSON, PC
Addresses:
SEARLE & CO, DEPT CHEM, SKOKIE, USA
SEARLE & CO, DEPT INFLAMMATORY DIS RES, SKOKIE, USA
SEARLE & CO, DEPT MOL PHARMACOL, SKOKIE, USA

Label: KURUMBAIL-1996
Title: STRUCTURAL BASIS FOR SELECTIVE INHIBITION OF CYCLOOXYGENASE-2 BY ANTI-INFLAMMATORY AGENTS
Journal: NATURE, vol. 384, p. 644-648, 1996
Citations: 405
Authors: KURUMBAIL, RG; STEVENS, AM; GIERSE, JK; MCDONALD, JJ; STEGEMAN, RA; PAK, JY; GILDEHAUS, D; MIYASHIRO, JM; PENNING, TD; SEIBERT, K; ISAKSON, PC; STALLINGS, WC
Addresses:
SEARLE & CO, 700 CHESTERFIELD PKWY N, ST LOUIS, USA
SEARLE & CO, , SKOKIE, USA

Label: HAWKEY-1999
Title: COX-2 INHIBITORS
Journal: LANCET, vol. 353, p. 307-314, 1999
Citations: 383
Authors: HAWKEY, CJ
Addresses:
UNIV NOTTINGHAM, Queens Med Ctr, Nottingham NG7 2UH, England
UNIV NOTTINGHAM, Queens Med Ctr, Nottingham NG7 2UH, England

Label: MASFERRER-2000
Title: ANTIANGIOGENIC AND ANTITUMOR ACTIVITIES OF CYCLOOXYGENASE-2 INHIBITORS
Journal: CANCER RES, vol. 60, p. 1306-1311, 2000
Citations: 375
Authors: MASFERRER, JL; LEAHY, KM; KOKI, AT; ZWEIFEL, BS; SETTLE, SL; WOERNER, BM; EDWARDS, DA; FLICKINGER, AG; MOORE, RJ; SEIBERT, K
Addresses:
GD SEARLE MONSANTO CO, T3G, St Louis, USA
GD SEARLE MONSANTO CO, , St Louis, USA

Label: SIMON-1999
Title: ANTI-INFLAMMATORY AND UPPER GASTROINTESTINAL EFFECTS OF CELECOXIB IN RHEUMATOID ARTHRITIS - A RANDOMIZED CONTROLLED TRIAL
Journal: JAMA-J AM MED ASSN, vol. 282, p. 1921-1928, 1999
Citations: 358
Authors: SIMON, LS; WEAVER, AL; GRAHAM, DY; KIVITZ, AJ; LIPSKY, PE; HUBBARD, RC; ISAKSON, PC; VERBURG, KM; YU, SS; ZHAO, WW; GEIS, GS
Addresses:
HARVARD UNIV, Sch Med, Boston, USA
HARVARD UNIV, Sch Med, Boston, USA
ARTHRIT CTR NEBRASKA, , Lincoln, USA
BAYLOR COLL MED, Vet Affairs Med Ctr, Houston, USA
Altoona Ctr Clin Res, , Altoona, USA
UNIV TEXAS, SW Med Ctr, Dallas, USA
SEARLE & CO, Dept Clin Res, Skokie, USA
SEARLE & CO, COX2 Technol, Skokie, USA

Label: SHENG-1997
Title: INHIBITION OF HUMAN COLON CANCER CELL GROWTH BY SELECTIVE INHIBITION OF CYCLOOXYGENASE-2
Journal: J CLIN INVEST, vol. 99, p. 2254-2259, 1997
Citations: 351
Authors: SHENG, HM; SHAO, JY; KIRKLAND, SC; ISAKSON, P; COFFEY, RJ; MORROW, J; BEAUCHAMP, RD; DUBOIS, RN
Addresses:
VANDERBILT UNIV, MED CTR, NASHVILLE, USA
VANDERBILT UNIV, MED CTR, NASHVILLE, USA
VANDERBILT UNIV, MED CTR, NASHVILLE, USA
VET ADM MED CTR, , NASHVILLE, USA
SEARLE & CO, DEPT INFLAMMATORY DIS RES, ST LOUIS, USA
UNIV LONDON, ROYAL POSTGRAD MED SCH, LONDON W12 0NN, ENGLAND

Label: GILROY-1999
Title: INDUCIBLE CYCLOOXYGENASE MAY HAVE ANTI-INFLAMMATORY PROPERTIES
Journal: NATURE MED, vol. 5, p. 698-701, 1999
Citations: 338
Authors: GILROY, DW; COLVILLE-NASH, PR; WILLIS, D; CHIVERS, J; PAUL-CLARK, MJ; WILLOUGHBY, DA
Addresses:
ST BARTHOLOMEWS HOSP, Dept Expt Pathol, London EC1M 6BQ, England
ST BARTHOLOMEWS HOSP, Dept Expt Pathol, London EC1M 6BQ, England

Label: MCADAM-1999
Title: SYSTEMIC BIOSYNTHESIS OF PROSTACYCLIN BY CYCLOOXYGENASE (COX)-2: THE HUMAN PHARMACOLOGY OF A SELECTIVE INHIBITOR OF COX-2
Journal: PROC NAT ACAD SCI USA, vol. 96, p. 272-277, 1999
Citations: 331
Authors: MCADAM, BF; CATELLA-LAWSON, F; MARDINI, IA; KAPOOR, S; LAWSON, JA; FITZGERALD, GA
Addresses:
UNIV PENN, Stellar Chance Labs 905, Philadelphia, USA
UNIV PENN, Stellar Chance Labs 905, Philadelphia, USA

Label: MUKHERJEE-2001
Title: RISK OF CARDIOVASCULAR EVENTS ASSOCIATED WITH SELECTIVE COX-2 INHIBITORS
Journal: JAMA-J AM MED ASSN, vol. 286, p. 954-959, 2001
Citations: 331
Authors: MUKHERJEE, D; NISSEN, SE; TOPOL, EJ
Addresses:
CLEVELAND CLIN FDN, Dept Cardiovasc Med, Cleveland, USA
CLEVELAND CLIN FDN, Dept Cardiovasc Med, Cleveland, USA

Label: SMITH-2000
Title: CYCLOOXYGENASES: STRUCTURAL, CELLULAR, AND MOLECULAR BIOLOGY
Journal: ANNU REV BIOCHEM, vol. 69, p. 145-182, 2000
Citations: 330
Authors: SMITH, WL; DEWITT, DL; GARAVITO, RM
Addresses:
MICHIGAN STATE UNIV, Dept Biochem, E Lansing, USA
MICHIGAN STATE UNIV, Dept Biochem, E Lansing, USA

Label: JONES-1999
Title: INHIBITION OF ANGIOGENESIS BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: INSIGHT INTO MECHANISMS AND IMPLICATIONS FOR CANCER GROWTH AND ULCER HEALING
Journal: NATURE MED, vol. 5, p. 1418-1423, 1999
Citations: 303
Authors: JONES, MK; WANG, HT; PESKAR, BM; LEVIN, E; ITANI, RM; SARFEH, IJ; TARNAWSKI, AS
Addresses:
VET ADM MED CTR, Dept Med, Long Beach, USA
VET ADM MED CTR, Dept Med, Long Beach, USA
VET ADM MED CTR, Dept Surg, Long Beach, USA
UNIV CALIF IRVINE, Dept Med, Irvine, USA
UNIV CALIF IRVINE, Dept Surg, Irvine, USA
RUHR UNIV BOCHUM, Dept Expt Clin Med, D-44780 Bochum, Germany

Label: SIMON-1998
Title: PRELIMINARY STUDY OF THE SAFETY AND EFFICACY OF SC-58635, A NOVEL CYCLOOXYGENASE 2 INHIBITOR - EFFICACY AND SAFETY IN TWO PLACEBO-CONTROLLED TRIALS IN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS, AND STUDIES OF GASTROINTESTINAL AND PLATELET EFFECTS
Journal: ARTHRITIS RHEUM, vol. 41, p. 1591-1602, 1998
Citations: 284
Authors: SIMON, LS; LANZA, FL; LIPSKY, PE; HUBBARD, RC; TALWALKER, S; SCHWARTZ, BD; ISAKSON, PC; GEIS, GS
Addresses:
HARVARD UNIV, Sch Med, Boston, USA
HARVARD UNIV, Sch Med, Boston, USA
HOUSTON INST CLIN RES, , Houston, USA
UNIV TEXAS, SW Med Ctr, Dallas, USA
SEARLE & CO, , Skokie, USA

Label: REDDY-1996
Title: EVALUATION OF CYCLOOXYGENASE-2 INHIBITOR FOR POTENTIAL CHEMOPREVENTIVE PROPERTIES IN COLON CARCINOGENESIS
Journal: CANCER RES, vol. 56, p. 4566-4569, 1996
Citations: 268
Authors: REDDY, BS; RAO, CV; SEIBERT, K
Addresses:
AMER HLTH FDN, DIV NUTR CARCINOGENESIS, VALHALLA, USA
SEARLE & CO, , ST LOUIS, USA