Fast Breaking Comment by Terry Speed

Terry Speed answers a few questions about this month's fast breaking paper in the field of Mathematics.

From •>>August 2003

Field: Mathematics
Article Title: "Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments"
Authors: Dudoit, S;Yang, YH;Callow, MJ;Speed, TP
Journal: STAT SINICA
Volume: 12
Page: 111-139
Year: JAN 2002
* Univ Calif Berkeley, Sch Publ Hlth, 140 Earl Warren Hall, 7360, Berkeley, CA 94720 USA.
* Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
* Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA.
* Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Sci Dept, Berkeley, CA 94720 USA.
* Walter & Eliza Hall Inst Med Res, Genet & Bioinformat Grp, Melbourne, Vic, Australia.

Why do you think your paper is highly cited?

It is in a fast-evolving area.

Does it describe a new discovery or a new methodology that's useful to others?

Yes, the latter.

Could you summarize the significance of your paper in layman's terms?

The paper gives some simple techniques for identifying differentially expressed genes in comparative microarray experiments.

How did you become involved in this research?

Through a request for assistance from our co-author Matthew Callow.

Terry Speed
Division of Genetics and Bioinformatics
The Walter & Eliza Hall Institute of Medical Research
Parkville, Victoria, Australia

ESI Special Topics, August 2003
Citing URL - http://www.esi-topics.com/fbp/2003/august03-TerrySpeed.html