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ESI Special Topics, November 2005
Citing URL: http://www.esi-topics.com/fmf/2005/november05-AugustineChoi.html

From •>>November 2005

Augustine M. K. Choi answers a few questions about this month's fast moving front in the field of Immunology.

Field: Immunology
Article: Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Authors: Otterbein, LE;Bach, FH;Alam, J;Soares, M;Lu, HT;Wysk, M;Davis, RJ;Flavell, RA;Choi, AMK
Journal: NATURE MED, 6 (4): 422-428, APR 2000
Yale Univ, Sch Med, Pulm & Crit Care Med Sect, 333 Cedar St, New Haven, CT 06520 USA.
Yale Univ, Sch Med, Pulm & Crit Care Med Sect, New Haven, CT 06520 USA.
Connecticut Healthcare Syst, Connecticut Vet Affairs, W Haven, CT 06516 USA.
Johns Hopkins Univ, Baltimore, MD 21205 USA.
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA.
Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA.
Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Howard Hughes Med Inst, Worcester, MA 01605 USA.
Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Program Mol Med, Worcester, MA 01605 USA.
Alton Ochsner Med Fdn & Ochsner Clin, Dept Mol Genet, New Orleans, LA 70121 USA.
Louisiana State Univ, Med Ctr, Dept Biochem & Mol Biol, New Orleans, LA USA. 


   Why do you think your paper is highly cited?


“...a novel property of carbon monoxide was highlighted in this paper”

It was the first paper to show anti-inflammatory effects of the gaseous molecule carbon monoxide, and the importance of the MAPK signaling pathway in this inflammatory effect.

   Does it describe a new discovery or a new methodology that's useful to others?

Yes, it’s a new discovery.

   Could you summarize the significance of your paper in layman's terms?

Carbon monoxide is a toxic gas which can be lethal if exposure is sustained. This study showed that carbon monoxide given at low concentrations in both cells and mice can be anti-inflammatory. Thus, a novel property of carbon monoxide was highlighted in this paper.

   How did you become involved in this research?

I have a long-standing interest in heme oxygenase-1, an enzyme which produces carbon monoxide in our cells and organs. We have shown that heme oxygenase-1 can be anti-inflammatory and cytoprotective and we learned from this study that perhaps the effect of heme oxygenase-1 may be mediated by carbon monoxide.End

Dr. Augustine M. K. Choi
Professor of Medicine 
Chief, Pulmonary, Allergy, and Critical Care Medicine Division
University of Pittsburgh School of Medicine
Pittsburgh, PA, USA

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ESI Special Topics, November 2005
Citing URL: http://www.esi-topics.com/fmf/2005/november05-AugustineChoi.html
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