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ESI Special Topics, September 2002
Citing URL: http://www.esi-topics.com/fmf/september02-EricNOlson.html

From •>>September 2002

Eric N. Olson, Ph.D. answers a few questions about this month's fast moving front in the field of Biology & Biochemistry.

Article title: "CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo"
Authors: Passier, R;Zeng, H;Frey, N;Naya, FJ;Nicol, RL;McKinsey, TA;Overbeek, P;Richardson, JA;Grant, SR;Olson, EN
Journal: J CLIN INVEST
Page: 105: (10) 1395-1406
Year: MAY 2000
Univ Texas, SW Med Ctr, Dept Biol Mol, 6000 Harry Hines Blvd, Dallas, TX 75235 USA.
Univ Texas, SW Med Ctr, Dept Biol Mol, Dallas, TX 75235 USA.
Univ N Texas, Ctr Hlth Sci, Inst Cardiovasc Res, Lab Cardiac & Vasc Mol Genet, Ft Worth, TX USA.
Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA.
Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA.


ST:  Why do you think your paper is highly cited?

This paper was highly cited because it described a novel signaling mechanism for cardiac hypertrophy and it presented a method for studying transcription factor activation in vivo using a specific strain of transgenic mice.

ST:  Could you summarize the significance of your paper in layman's terms?

The paper identifies a biochemical pathway that causes cardiac enlargement and heart failure in response to stress. The components of this pathway can be used as targets for development of drugs to prevent or reverse this pathological response of the heart.

ST:  How did you become involved in this research?

We have worked for the past several years to decipher the signaling pathways that control cardiac growth. This study was a logical extension of our earlier work.End

Eric N. Olson, Ph.D.
Department of Molecular Biology
UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd.
Dallas, TX 75390-9148
   

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ESI Special Topics, September 2002
Citing URL: http://www.esi-topics.com/fmf/september02-EricNOlson.html
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