Hepatitis C - Abstract of the Top Paper

elow is the full abstract of the top paper in the special topic Hepatitis C. This paper is listed as a Highly Cited Paper (last 10 years) in ISI Essential Science IndicatorsWeb based product. Clicking on the Web of Science^® button in the paper listing of ISI Essential Science Indicators will take the user to Web of Science if the user has a valid subscription for that product (otherwise, the button will not appear). Web of Science provides a more detailed listing for the paper including an abstract (if available), plus other citation linking capabilities. The "Go to Document Delivery" button allows users to order the full text of a paper from ISI's document ordering service.

SOURCE: ISI Essential Science Indicators Web based product from the July 1, 2002 update covering a ten year plus four month period, January 1992 - April 30, 2002.

"TYPING HEPATITIS-C VIRUS BY POLYMERASE CHAIN-REACTION WITH TYPE-SPECIFIC PRIMERS - APPLICATION TO CLINICAL SURVEYS AND TRACING INFECTIOUS SOURCES"

RANK: #1
Total Cites: 1,023

Authors:
OKAMOTO H, SUGIYAMA Y, OKADA S, KURAI K, AKAHANE Y, SUGAI Y, TANAKA T, SATO K, TSUDA F, MIYAKAWA Y, MAYUMI M

Journal:
JOURNAL OF GENERAL VIROLOGY 73: 673-679 Part 3 MAR 1992

Document type: Article

Language: English

Cited References: 29

Times Cited: 1034

Abstract:
Based on variation in nucleotide sequence within restricted regions in the putative C (core) gene of hepatitis C virus (HCV), four groups of HCV have been postulated in a panel of 44 HCV isolates. They were provisionally designated types I, II, III and IV. A method for typing HCV was developed, depending on the amplification of a C gene sequence by polymerase chain reaction using a universal primer (sense) and a mixture of four type-specific primers (antisense). HCV types were determined by the size of the products specific to each of them. Type II was found in HCV samples from 131 (82%) of 159 blood donors, more often than in those from 48 (60%) of 80 patients with non-A, non-B (NANB) liver disease in Japan (P < 0.01). In 11 haemophiliacs who had received imported coagulation factor concentrates, type I was found in five, as against type II in four. Double infection with two different HCV types was found in two patients with chronic NANB liver disease (types I and II; II and III) and two haemophiliacs (types I and II; I and III). HCV types were identical in mother and baby in each of two examples of perinatal transmission, and were also identical in donor and recipient in a case of accidental needle exposure.

KeyWords Plus:
NON-B-HEPATITIS, NON-A, BLOOD-DONORS, ANTIBODIES, GENOME, CDNA, TRANSMISSION, SEQUENCES, DIAGNOSIS, JAPAN

Addresses:
JICHI MED SCH,DIV IMMUNOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN
HIROSHIMA UNIV,DEPT HYG,HIROSHIMA 734,JAPAN
YAMANASHI MED COLL,DEPT INTERNAL MED 1,YAMANASHI 40938,JAPAN
IWAKI KYORITSU GEN HOSP,DEPT INTERNA MED,IWAKI,FUKUSHIMA 973,JAPAN
JAPANESE RED CROSS BLOOD CTR,SAITAMA 362,JAPAN
KITASATO INST,DEPT IMMUNOL,TOKYO 108,JAPAN
MITA INST,TOKYO 108,JAPAN

Publisher:
SOC GENERAL MICROBIOLOGY, READING

IDS Number:
HH456

ISSN:
0022-1317

Abstract from Web of Science^®

ESI Special Topics, September 2002
Citing URL - http://www.esi-topics.com/hepc/interviews/toppaper.html