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New Hot Paper Comments

By Bruce W. Hollis

ESI Special Topics, March 2006
Citing URL - http://www.esi-topics.com/nhp/2006/march-06-BruceWHollis.html

Bruce W. Hollis answers a few questions about this month's new hot paper in the field of Agricultural Sciences.


From •>>March 2006

Field: Agricultural Sciences
Article Title: Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: Implications for establishing a new effective dietary intake recommendation for vitamin D
Authors: Hollis, BW
Journal: J NUTR
Volume: 135
Issue: 2
Page: 317-322
Year: FEB 2005
* Med Univ S Carolina, Dept Pediat, 171 Ashley Ave, Charleston, SC 29425 USA.
* Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA.
* Med Univ S Carolina, Dept Biochem, Charleston, SC 29425 USA.
* Med Univ S Carolina, Dept Mol Biol, Charleston, SC 29425 USA.

ST:  Why do you think your paper is highly cited?


“ The article provides an excellent background for the regulatory agencies, such as the FDA, to reexamine the dietary requirement vitamin D and reset the recommendations at a realistic value.”

The dietary requirement for vitamin D in most of the population has been wrong since the day it was made. This article was written in a systematic fashion to demonstrate how the actual requirement for vitamin D should be established and how absurd and potentially harmful the current recommendations are. This is especially true in people of color whose skin at northern latitudes largely prevents the photo-conversion of vitamin D in the epidermis.

ST:  Does it describe a new discovery or a new methodology that's useful to others?

The article provides an excellent background for the regulatory agencies, such as the FDA, to reexamine the dietary requirement vitamin D and reset the recommendations at a realistic value.

ST:  Could you summarize the significance of your paper in layman's terms?

Vitamin D deficiency is a very serious health problem. Most people tend to think of it only in terms of skeletal problems; however, it is much more than that. Vitamin D deficiency has now been linked with a multitude of neoplasms, autoimmune dysfunction, compromised innate immunity and neurodevelopment in utero. Vitamin D is made in huge amounts when we go into intense sun. A fair-skinned individual can produce approximately 20,000 IU in 10 minutes’ time with a total body exposure. A person with significant pigmentation will require up to 10 times the exposure to make an equivalent amount. In the winter at the latitude of Chicago, even a fair person cannot photo-produce vitamin D from mid-October through March. Thus, it is VERY important to have a realistic vitamin D recommendation as the current 200 IU/day recommendation is a joke.

It is maddening to me to hear physicians say "drink some milk and you will obtain all the vitamin D you need." It is wrong and harmful to the patient. No one should have a circulating 25(OH) D level—this is the metabolite that defines nutritional vitamin D status—less than 80 nmol. I try to keep my own level at 125 nmol minimum and consume between 2,000-8,000 IU/day depending on the season.

ST:  How did you become involved in this research, and were any problems encountered along the way?

I have been involved in vitamin D metabolism and nutrition for the past 30 years and have published more than 150 papers on the topic. Our current funding from the NIH is to study the vitamin D requirements during pregnancy and lactation. These studies include dosing vitamin D to pregnant and lactating women at up to 6,000 IU/day. When these grants went to the study section, we got a great score and were ready to start the project. When we were reviewed by our IRB they referred us to the FDA who requested we get a full blown IND number. After six months of writing and talking with the FDA we were awarded the IND. We started the project and have not looked back.End

Bruce W. Hollis, Ph.D.
Professor of Pediatrics 
And Professor of Biochemistry & Molecular Biology
Director of Pediatric Nutritional Sciences 
Medical University of South Carolina
Charleston, SC, USA

ESI Special Topics, March 2006
Citing URL - http://www.esi-topics.com/nhp/2006/march-06-BruceWHollis.html

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