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Yinon Ben-Neriah
answers a few questions about this month's new hot paper in field of
Immunology.
From
•>>May 2002
Field: Immunology
Article Title: Phosphorylation meets
ubiquitination: The control of NF-kappa B activity
Authors: Karin,
M,:Ben-Neriah, Y
Journal: ANNU REV IMMUNOL
Volume: 18:
Page: 621-+
Year: 2000
* Univ Calif San Diego, Lab Gene Regulat & Signal
Transduct, Dept Pharmacol, La Jolla, CA 92093 USA.
* Univ Calif San Diego, Lab Gene Regulat & Signal
Transduct, Dept Pharmacol, La Jolla, CA 92093 USA.
* Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr
Immunol, IL-91120 Jerusalem, Israel.
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Why do you think your paper is highly cited?
Our review
relates to two intersecting fields of high interest: signal
transduction via phosphorylation-coupled protein ubiquitination and
the regulation of innate immunity. Part of the interest stems from the
medical implications of the reviewed topic.
Does it describe a new discovery or new methodology that's
useful to
others?
It reviews a burst of new discoveries made in the past few years.
Can you give us some background on this research?
NF-kappa B is responsible for transcribing genes central to the
body’s defense against invasive agents. Sometimes, however, this
transcription factor acts uncontrollably, resulting in the body’s
over-reaction, as manifested by asthma and rheumatoid arthritis. In
addition, NF-kappa B is liable to cause damage through its
recruitment by a number of pathogens, such as the AIDS virus. It is
also an important element in the resistance of many human tumors to
chemotherapy. In the past few years two important enzymatic
regulators of NF-kappa B have been identified: a protein kinase and
a ubiquitin ligase, which act jointly to destroy the specific
cellular inhibitor of NF-kappa B , known as I-kappa B.
Yinon Ben-Neriah
Lautenberg Center for Immunology
Hebrew University, Hadassah Medical School
Jerusalem, ISRAEL
 Michael
Karin
Laboratory of Gene Regulation and Signal Transduction
Department of Pharmacology
University of California, San Diego
La Jolla, CA, USA
UCSD's Michael Karin Follows the Cellular Pathways - The
20 microns between the cell membrane and the genetic material in the
cell nucleus is the playground of the molecules of signal transduction,
of the intricate and multifaceted redundancy of the pathways that take
signals from the membrane and convert them into the exquisitely
selective control of our genes. Within these pathways, the regulation
of gene transcription is carried out by a multitude of hormones and
growth factor...
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ESI Special Topics, May
2002
Citing URL - http://www.esi-topics.com/nhp/comments/may-02-YinonBen-Neriah.html
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