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New Hot Paper Comments

By Patrice Courvalin, MD, FRCP

ESI Special Topics, November 2002
Citing URL - http://www.esi-topics.com/nhp/comments/november-02-PatriceCourvalin.html

Patrice Courvalin, MD, FRCP answers a few questions about this month's new hot paper in the field of Microbiology.

From •>>November 2002

Field: Microbiology
Article Title: "Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America"
 Authors: Tait-Kamradt, A;Davies, T;Appelbaum, PC;Depardieu, F;Courvalin, P;Petitpas, J;Wondrack, L;Walker, A;Jacobs, MR;Sutcliffe, J
Journal: ANTIMICROB AGENTS CHEMOTHER
Volume: 44
Page: 3395-3401
Year: DEC 2000
* Pfizer Inc, Global Res & Dev, Dept Infect Dis, RAIID, Eastern Point Rd, Groton, CT 06340 USA.
* Pfizer Inc, Global Res & Dev, Dept Infect Dis, RAIID, Groton, CT 06340 USA.
* Case Western Reserve Univ, Cleveland, OH 44106 USA.
* Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA.
* Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris, France.

ST:  Why do you think your paper is highly cited?

It is highly cited because it deals with a major human pathogen, a widely used class of drugs, and reports new mechanisms of resistance that complicate detection and interpretation of in vitro susceptibility tests.

ST:  Does it describe a new discovery or new methodology that's useful to others?

Our paper describes a new discovery. However, are not all scientific manuscripts supposed to report new findings?

ST:  What was the circumstance that led you to do this research?

It was the observation of a new resistance phenotype.

ST:  Could you summarize the significance of your paper in layman's terms?

Clinical isolates of pneumococci that displayed unusual resistance to erythromycin and derivative antibiotics were shown to have ribrosome alterations following chromosomal mutations.End

Patrice Courvalin, MD, FRCP
Unité des Agents Antibactériens
Institut Pasteur
25-28, rue du Docteur Roux
75724 Paris cedex 15
France

SI Special Topics, November 2002
Citing URL - http://www.esi-topics.com/nhp/comments/november-02-PatriceCourvalin.html

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