***Article 1
Total Cites: 1854
Article Title: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
Authors: Polymeropoulos, MH, Lavedan, C, Leroy, E, Ide, SE, Dehejia, A, Dutra, A, Pike, B, Root, H, Rubenstein, J, Boyer, R, Stenroos, ES, Chandrasekharappa, S, Athanassiadou, A, Papapetropoulos, T, Johnson, WG, Lazzarini, AM, Duvoisin, RC, Diiorio, G, Golbe, LI, Nussbaum, RL
Journal: SCIENCE
Volume: 276
Page: 2045-2047
Year: 1997
Addresses:
· NIH, LAB GENE TRANSFER, NATL HUMAN GENOME RES INST, BETHESDA, MD, USA
· UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, PISCATAWAY, NJ, USA
· UNIV NAPLES 2, INST NEUROL SCI, FAC MED, NAPLES, ITALY
· UNIV PATRAS, SCH MED, PATRAS, GREECE
· NIH, LAB GENET DIS RES, NATL HUMAN GENOME RES INST, BLDG 10, BETHESDA, MD, USA

***Article 2
Total Cites: 1104
Article Title: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Authors: Kitada, T, Asakawa, S, Hattori, N, Matsumine, H, Yamamura, Y, Minoshima, S, Yokochi, M, Mizuno, Y, Shimizu, N
Journal: NATURE
Volume: 392
Page: 605-608
Year: 1998
Addresses:
· Keio Univ, Sch Med, Dept Biol Mol, Shinjuku Ku, Tokyo, Japan
· Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo, Japan
· Hiroshima Univ, Sch Med, Dept Hlth Sci, Minami Ku, Hiroshima, Japan
· Tokyo Metropolitan Ebara Hosp, Dept Neurol, Ota Ku, Tokyo, Japan

***Article 3
Total Cites: 683
Article Title: Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Authors: Betarbet, R, Sherer, TB, Mackenzie, G, Garcia-osuna, M, Panov, AV, Greenamyre, JT
Journal: NATURE NEUROSCIENCE
Volume: 3
Page: 1301-1306
Year: 2000
Addresses:
· Emory Univ, Dept Neurol, Atlanta, GA, USA
· Emory Univ, Dept Neurol, 1639 Pierce Dr,WMB 6000, Atlanta, GA, USA

***Article 4
Total Cites: 573
Article Title: Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease
Authors: Limousin, P, Krack, P, Pollak, P, Benazzouz, A, Ardouin, C, Hoffmann, D, Benabid, AL
Journal: NEW ENGL J MED
Volume: 339
Page: 1105-1111
Year: 1998
Addresses:
· Univ Grenoble 1, Dept Clin & Biol Neurosci, Grenoble, France
· MRC, Human Movement & Balance Unit, London, England
· Univ Kiel, Dept Neurol, Kiel, Germany
· Univ Grenoble 1, Dept Clin & Biol Neurosci, BP 217, Grenoble, France

***Article 5
Total Cites: 555
Article Title: alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
Authors: Spillantini, MG, Crowther, RA, Jakes, R, Hasegawa, M, Goedert, M
Journal: P NATL ACAD SCI USA
Volume: 95
Page: 6469-6473
Year: 1998
Addresses:
· MRC, Mol Biol Lab, Cambridge, England
· Univ Cambridge, MRC, Ctr Brain Repair, Cambridge, England
· Univ Cambridge, Dept Neurol, Cambridge, England
· MRC, Mol Biol Lab, Hills Rd, Cambridge, England

***Article 6
Total Cites: 548
Article Title: A Drosophila model of Parkinson's disease
Authors: Feany, MB, Bender, WW
Journal: NATURE
Volume: 404
Page: 394-398
Year: 2000
Addresses:
· Brigham & Womens Hosp, Dept Pathol, Div Neuropathol, Boston, MA, USA
· Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA, USA
· Brigham & Womens Hosp, Dept Pathol, Div Neuropathol, 75 Francis St, Boston, MA, USA

***Article 7
Total Cites: 526
Article Title: Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
Authors: Freed, CR, Greene, PE, Breeze, RE, Tsai, WY, Dumouchel, W, Kao, R, Dillon, S, Winfield, H, Culver, S, Trojanowski, JQ, Eidelberg, D, Fahn, S
Journal: NEW ENGL J MED
Volume: 344
Page: 710-719
Year: 2001
Addresses:
· Univ Colorado, Sch Med, Div Clin Pharmacol, Denver, CO, USA
· Columbia Univ, Coll Phys & Surg, New York, NY, USA
· AT&T Shannon Lab, Florham Park, NJ, USA
· Univ Penn, Med Ctr, Philadelphia, PA, USA
· N Shore Univ Hosp, Manhasset, NY, USA
· Univ Colorado, Sch Med, Div Clin Pharmacol, C-237,4200 E 9th Ave, Denver, CO, USA

***Article 8
Total Cites: 524
Article Title: Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
Authors: Shimura, H, Hattori, N, Kubo, S, Mizuno, Y, Asakawa, S, Minoshima, S, Shimizu, N, Iwai, K, Chiba, T, Tanaka, K, Suzuki, T
Journal: NATURE GENETICS
Volume: 25
Page: 302-305
Year: 2000
Addresses:
· Tokyo Metropolitan Inst Med Sci, Tokyo, Japan
· Japan Sci & Technol Corp, JST, CREST, Bunkyo Ku, Tokyo, Japan
· Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo, Japan
· Keio Univ, Sch Med, Dept Mol Biol, Shinjuku Ku, Tokyo, Japan
· Kyoto Univ, Grad Sch Biostudies, Dept Mol & Syst Biol, Kyoto, Japan
· Tokyo Metropolitan Inst Med Sci, Bunkyo Ku, Tokyo, Japan

***Article 9
Total Cites: 467
Article Title: Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with lewy bodies
Authors: Baba, M, Nakajo, S, Tu, PH, Tomita, T, Nakaya, K, Lee, VMY, Trojanowski, JQ, Iwatsubo, T
Journal: AM J PATHOL
Volume: 152
Page: 879-884
Year: 1998
Addresses:
· Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Neuropathol & Neurosci, Bunkyo Ku, Tokyo, Japan
· Showa Univ, Sch Pharmaceut Sci, Biol Chem Lab, Tokyo, Japan
· Univ Penn, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA, USA

***Article 10
Total Cites: 429
Article Title: Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease
Authors: Shimura, H, Schlossmacher, MC, Hattori, N, Frosch, MP, Trockenbacher, A, Schneider, R, Mizuno, Y, Kosik, KS, Selkoe, DJ
Journal: SCIENCE
Volume: 293
Page: 263-269
Year: 2001
Addresses:
· Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA, USA
· Juntendo Univ, Sch Med, Dept Neurol, Tokyo, Japan
· Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol, Boston, MA, USA
· Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA, USA
· Innsbruck Univ, Inst Biochem, Innsbruck, Austria

***Article 11
Total Cites: 427
Article Title: Parkinson's disease - First of two parts
Authors: Lang, AE, Lozano, AM
Journal: NEW ENGL J MED
Volume: 339
Page: 1044-1053
Year: 1998
Addresses:
· Toronto Hosp, Toronto, Canada
· Univ Toronto, Dept Med, Div Neurol, Toronto, Canada
· Univ Toronto, Dept Surg, Div Neurosurg, Toronto, Canada
· Toronto Hosp, Morton & Gloria Shulman Movement Disorders Ctr, Toronto, Canada
· Toronto Hosp, 399 Bathurst St,MP 11, Toronto, Canada

***Article 12
Total Cites: 422
Article Title: Functional recovery in parkinsonian monkeys treated with GDNF
Authors: Gash, DM, Zhang, ZM, Ovadia, A, Cass, WA, Yi, A, Simmerman, L, Russell, D, Martin, D, Lapchak, PA, Collins, F, Hoffer, BJ, Gerhardt, GA
Journal: NATURE
Volume: 380
Page: 252-255
Year: 1996
Addresses:
· AMGEN INC, THOUSAND OAKS, CA, USA
· UNIV COLORADO, HLTH SCI CTR, DEPT PHARMACOL, NEUROSCI TRAINING PROGRAM, DENVER, CO, USA
· UNIV COLORADO, HLTH SCI CTR, DEPT PSYCHIAT, NEUROSCI TRAINING PROGRAM, DENVER, CO, USA
· UNIV COLORADO, HLTH SCI CTR, ROCKY MT CTR SENSOR TECHNOL, DENVER, CO, USA
· UNIV KENTUCKY, COLL MED, DEPT ANAT & NEUROBIOL, LEXINGTON, KY, USA

***Article 13
Total Cites: 419
Article Title: Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
Authors: Conway, KA, Harper, JD, Lansbury, PT
Journal: NAT MED
Volume: 4
Page: 1318-1320
Year: 1998
Addresses:
· Harvard Univ, Sch Med, Harvard Inst Med, Brigham & Womens Hosp,Ctr Neurol Dis, Boston, MA, USA
· Harvard Univ, Sch Med, Harvard Inst Med, Dept Neurol, Boston, MA, USA

***Article 14
Total Cites: 409
Article Title: Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
Authors: Kim, JH, Auerbach, JM, Rodriguez-gomez, JA, Velasco, I, Gavin, D, Lumelsky, N, Lee, SH, Nguyen, J, Sanchez-pernaute, R, Bankiewicz, K, Mckay, R
Journal: NATURE
Volume: 418
Page: 50-56
Year: 2002
Addresses:
· NINCDS, Mol Biol Lab, NIH, Bethesda, MD, USA

***Article 15
Total Cites: 397
Article Title: Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
Authors: Kordower, JH, Emborg, ME, Bloch, J, Ma, SY, Chu, YP, Leventhal, L, Mcbride, J, Chen, EY, Palfi, S, Roitberg, BZ, Brown, WD, Holden, JE, Pyzalski, R, Taylor, MD, Carvey, P, Ling, ZD, Trono, D, Hantraye, P, Deglon, N, Aebischer, P
Journal: SCIENCE
Volume: 290
Page: 767-773
Year: 2000
Addresses:
· Rush Presbyterian St Lukes Med Ctr, Dept Neurol Sci, Chicago, IL, USA
· Rush Presbyterian St Lukes Med Ctr, Dept Pharmacol, Chicago, IL, USA
· Univ Lausanne, Sch Med, Div Surg Res, Lausanne, Switzerland
· Univ Lausanne, Sch Med, Gene Therapy Ctr, Lausanne, Switzerland
· Univ Wisconsin, Dept Med Phys, Madison, WI, USA
· Univ Wisconsin, Dept Radiol, Madison, WI, USA
· Univ Geneva, Fac Med, Dept Genet & Microbiol, Geneva, Switzerland
· Serv Hosp Frederic Joliot, CEA, Dept Rech Med, Direct Rech Med,CNRS,Unite Rech Associe 2210, Orsay, France
· EPFL, Swiss Fed Inst Technol, Lausanne, Switzerland
· Rush Presbyterian St Lukes Med Ctr, Dept Neurol Sci, 1653 W Congress Pkwy, Chicago, IL, USA

***Article 16
Total Cites: 394
Article Title: A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa
Authors: Rascol, O, Brooks, DJ, Korczyn, AD, De Deyn, PP, Clarke, CE, Lang, AE, 056 Study Grp
Journal: NEW ENGL J MED
Volume: 342
Page: 1484-1491
Year: 2000
Addresses:
· Univ Hosp, INSERM, U455, Neuropharmacol Unit,Clin Invest Ctr, Toulouse, France
· Hammersmith Hosp, Imperial Coll Sch Med, Div Neurosci, London, England
· Tel Aviv Univ, Sch Med, Dept Neurol, Ramat Aviv, Israel
· Born Bunge Fdn, Gen Hosp Middelheim, Dept Neurol, Antwerp, Belgium
· Univ Antwerp, Antwerp, Belgium
· Univ Birmingham, Dept Neurol, Birmingham, England
· Univ Toronto, Dept Med Neurol, Toronto, Canada
· Toronto Western Hosp, Toronto, Canada
· Fac Med Toulouse, Serv Pharmacol Med & Clin, 37 Allees Jules Guesde, Toulouse, France

***Article 17
Total Cites: 388
Article Title: Etiology and pathogenesis of Parkinson's disease
Authors: Olanow, CW, Tatton, WG
Journal: ANNUAL REVIEW OF NEUROSCIENCE
Volume: 22
Page: 123-144
Year: 1999
Addresses:
· Mt Sinai Med Ctr, Dept Neurol, New York, NY, USA

***Article 18
Total Cites: 375
Article Title: Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study
Authors: Baron, MS, Vitek, JL, Bakay, RAE, Green, J, Kaneoke, Y, Hashimoto, T, Turner, RS, Woodard, JL, Cole, SA, Mcdonald, WM, Delong, MR
Journal: ANNALS OF NEUROLOGY
Volume: 40
Page: 355-366
Year: 1996
Addresses:
· EMORY UNIV, DEPT NEUROSURG, SCH MED, ATLANTA, GA, USA
· EMORY UNIV, DEPT PSYCHIAT, SCH MED, ATLANTA, GA, USA
· EMORY UNIV, DEPT NEUROL, SCH MED, 6000 WMRB, ATLANTA, GA, USA

***Article 19
Total Cites: 372
Article Title: Neuropathology of Parkinson's disease
Authors: Forno, LS
Journal: J NEUROPATH EXP NEUR
Volume: 55
Page: 259-272
Year: 1996
Addresses:
· VA PALO ALTO HLTH CARE SYST, DEPT PATHOL 113, 3801 MIRANDA AVE, PALO ALTO, CA, USA

***Article 20
Total Cites: 371
Article Title: alpha-synuclein locus triplication causes Parkinson's disease
Authors: Singleton, AB, Farrer, M, Johnson, J, Singleton, A, Hague, S, Kachergus, J, Hulihan, M, Peuralinna, T, Dutra, A, Nussbaum, R, Lincoln, S, Crawley, A, Hanson, M, Maraganore, D, Adler, C, Cookson, MR, Muenter, M, Baptista, M, Miller, D, Blancato, J, Hardy, J, Gwinn-hardy, K
Journal: SCIENCE
Volume: 302
Page: 841-841
Year: 2003
Addresses:
· NIA, Neurogenet Lab, NIH, Bethesda, MD, USA
· NINDS, Neurogenet Branch, NIH, Bethesda, MD, USA
· NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD, USA
· Mayo Clin, Genet Neurodgenerat Lab, Jacksonville, FL, USA
· Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN, USA
· Mayo Clin, Dept Neurol, Scottsdale, AZ, USA
· Georgetown Univ, Med Ctr, Washington, DC, USA