Label: Polymeropoulos-1997
Title: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
Journal: SCIENCE, vol. 276, p. 2045-2047, 1997
Citations: 1854
Authors: Polymeropoulos, MH; Lavedan, C; Leroy, E; Ide, SE; Dehejia, A; Dutra, A; Pike, B; Root, H; Rubenstein, J; Boyer, R; Stenroos, ES; Chandrasekharappa, S; Athanassiadou, A; Papapetropoulos, T; Johnson, WG; Lazzarini, AM; Duvoisin, RC; DiIorio, G; Golbe, LI; Nussbaum, RL
Addresses:
NIH, LAB GENE TRANSFER, NATL HUMAN GENOME RES INST, BETHESDA, USA
UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, PISCATAWAY, USA
UNIV NAPLES 2, INST NEUROL SCI, FAC MED, NAPLES, ITALY
UNIV PATRAS, SCH MED, PATRAS, GREECE
NIH, LAB GENET DIS RES, NATL HUMAN GENOME RES INST, BLDG 10, BETHESDA, USA

Label: Kitada-1998
Title: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Journal: NATURE, vol. 392, p. 605-608, 1998
Citations: 1104
Authors: Kitada, T; Asakawa, S; Hattori, N; Matsumine, H; Yamamura, Y; Minoshima, S; Yokochi, M; Mizuno, Y; Shimizu, N
Addresses:
Keio Univ, Sch Med, Tokyo, Japan
Juntendo Univ, Sch Med, Tokyo, Japan
Hiroshima Univ, Sch Med, Hiroshima, Japan
Tokyo Metropolitan Ebara Hosp, Dept Neurol, Tokyo, Japan

Label: Betarbet-2000
Title: Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Journal: NAT NEUROSCI, vol. 3, p. 1301-1306, 2000
Citations: 683
Authors: Betarbet, R; Sherer, TB; MacKenzie, G; Garcia-Osuna, M; Panov, AV; Greenamyre, JT
Addresses:
Emory Univ, Dept Neurol, Atlanta, USA
Emory Univ, Dept Neurol, Atlanta, USA

Label: Limousin-1998
Title: Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease
Journal: NEW ENGL J MED, vol. 339, p. 1105-1111, 1998
Citations: 573
Authors: Limousin, P; Krack, P; Pollak, P; Benazzouz, A; Ardouin, C; Hoffmann, D; Benabid, AL
Addresses:
Univ Grenoble 1, Dept Clin & Biol Neurosci, Grenoble, France
MRC, Human Movement & Balance Unit, London, England
Univ Kiel, Dept Neurol, Kiel, Germany
Univ Grenoble 1, Dept Clin & Biol Neurosci, Grenoble, France

Label: Spillantini-1998
Title: alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
Journal: P NATL ACAD SCI USA, vol. 95, p. 6469-6473, 1998
Citations: 555
Authors: Spillantini, MG; Crowther, RA; Jakes, R; Hasegawa, M; Goedert, M
Addresses:
MRC, Mol Biol Lab, Cambridge, England
Univ Cambridge, MRC, Cambridge, England
Univ Cambridge, Dept Neurol, Cambridge, England
MRC, Mol Biol Lab, Cambridge, England

Label: Feany-2000
Title: A Drosophila model of Parkinson's disease
Journal: NATURE, vol. 404, p. 394-398, 2000
Citations: 548
Authors: Feany, MB; Bender, WW
Addresses:
Brigham & Womens Hosp, Dept Pathol, Boston, USA
Harvard Univ, Sch Med, Boston, USA
Brigham & Womens Hosp, Dept Pathol, Boston, USA

Label: Freed-2001
Title: Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
Journal: NEW ENGL J MED, vol. 344, p. 710-719, 2001
Citations: 526
Authors: Freed, CR; Greene, PE; Breeze, RE; Tsai, WY; DuMouchel, W; Kao, R; Dillon, S; Winfield, H; Culver, S; Trojanowski, JQ; Eidelberg, D; Fahn, S
Addresses:
Univ Colorado, Sch Med, Denver, USA
Columbia Univ, Coll Phys & Surg, New York, USA
AT&T Shannon Lab, , Florham Park, USA
Univ Penn, Med Ctr, Philadelphia, USA
N Shore Univ Hosp, , Manhasset, USA
Univ Colorado, Sch Med, Denver, USA

Label: Shimura-2000
Title: Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
Journal: NAT GENET, vol. 25, p. 302-305, 2000
Citations: 524
Authors: Shimura, H; Hattori, N; Kubo, S; Mizuno, Y; Asakawa, S; Minoshima, S; Shimizu, N; Iwai, K; Chiba, T; Tanaka, K; Suzuki, T
Addresses:
Tokyo Metropolitan Inst Med Sci, , Tokyo, Japan
Japan Sci & Technol Corp, JST, Tokyo, Japan
Juntendo Univ, Sch Med, Tokyo, Japan
Keio Univ, Sch Med, Tokyo, Japan
Kyoto Univ, Grad Sch Biostudies, Kyoto, Japan
Tokyo Metropolitan Inst Med Sci, Bunkyo Ku, Tokyo, Japan

Label: Baba-1998
Title: Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with lewy bodies
Journal: AM J PATHOL, vol. 152, p. 879-884, 1998
Citations: 467
Authors: Baba, M; Nakajo, S; Tu, PH; Tomita, T; Nakaya, K; Lee, VMY; Trojanowski, JQ; Iwatsubo, T
Addresses:
Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo, Japan
Showa Univ, Sch Pharmaceut Sci, Tokyo, Japan
Univ Penn, Dept Pathol & Lab Med, Philadelphia, USA

Label: Shimura-2001
Title: Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease
Journal: SCIENCE, vol. 293, p. 263-269, 2001
Citations: 429
Authors: Shimura, H; Schlossmacher, MC; Hattori, N; Frosch, MP; Trockenbacher, A; Schneider, R; Mizuno, Y; Kosik, KS; Selkoe, DJ
Addresses:
Harvard Univ, Brigham & Womens Hosp, Boston, USA
Juntendo Univ, Sch Med, Tokyo, Japan
Harvard Univ, Brigham & Womens Hosp, Boston, USA
Harvard Univ, Brigham & Womens Hosp, Boston, USA
Innsbruck Univ, Inst Biochem, Innsbruck, Austria

Label: Lang-1998
Title: Parkinson's disease - First of two parts
Journal: NEW ENGL J MED, vol. 339, p. 1044-1053, 1998
Citations: 427
Authors: Lang, AE; Lozano, AM
Addresses:
Toronto Hosp, , Toronto, Canada
Univ Toronto, Dept Med, Toronto, Canada
Univ Toronto, Dept Surg, Toronto, Canada
Toronto Hosp, Morton & Gloria Shulman Movement Disorders Ctr, Toronto, Canada
Toronto Hosp, 399 Bathurst St,MP 11, Toronto, Canada

Label: Gash-1996
Title: Functional recovery in parkinsonian monkeys treated with GDNF
Journal: NATURE, vol. 380, p. 252-255, 1996
Citations: 422
Authors: Gash, DM; Zhang, ZM; Ovadia, A; Cass, WA; Yi, A; Simmerman, L; Russell, D; Martin, D; Lapchak, PA; Collins, F; Hoffer, BJ; Gerhardt, GA
Addresses:
AMGEN INC, , THOUSAND OAKS, USA
UNIV COLORADO, HLTH SCI CTR, DEPT PHARMACOL, NEUROSCI TRAINING PROGRAM, DENVER, USA
UNIV COLORADO, HLTH SCI CTR, DEPT PSYCHIAT, NEUROSCI TRAINING PROGRAM, DENVER, USA
UNIV COLORADO, HLTH SCI CTR, ROCKY MT CTR SENSOR TECHNOL, DENVER, USA
UNIV KENTUCKY, COLL MED, DEPT ANAT & NEUROBIOL, LEXINGTON, USA

Label: Conway-1998
Title: Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
Journal: NAT MED, vol. 4, p. 1318-1320, 1998
Citations: 419
Authors: Conway, KA; Harper, JD; Lansbury, PT
Addresses:
Harvard Univ, Sch Med, Boston, USA
Harvard Univ, Sch Med, Boston, USA

Label: Kim-2002
Title: Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
Journal: NATURE, vol. 418, p. 50-56, 2002
Citations: 409
Authors: Kim, JH; Auerbach, JM; Rodriguez-Gomez, JA; Velasco, I; Gavin, D; Lumelsky, N; Lee, SH; Nguyen, J; Sanchez-Pernaute, R; Bankiewicz, K; McKay, R
Addresses:
NINCDS, Mol Biol Lab, Bethesda, USA

Label: Kordower-2000
Title: Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
Journal: SCIENCE, vol. 290, p. 767-773, 2000
Citations: 397
Authors: Kordower, JH; Emborg, ME; Bloch, J; Ma, SY; Chu, YP; Leventhal, L; McBride, J; Chen, EY; Palfi, S; Roitberg, BZ; Brown, WD; Holden, JE; Pyzalski, R; Taylor, MD; Carvey, P; Ling, ZD; Trono, D; Hantraye, P; Deglon, N; Aebischer, P
Addresses:
Rush Presbyterian St Lukes Med Ctr, Dept Neurol Sci, Chicago, USA
Rush Presbyterian St Lukes Med Ctr, Dept Pharmacol, Chicago, USA
Univ Lausanne, Sch Med, Lausanne, Switzerland
Univ Lausanne, Sch Med, Lausanne, Switzerland
Univ Wisconsin, Dept Med Phys, Madison, USA
Univ Wisconsin, Dept Radiol, Madison, USA
Univ Geneva, Fac Med, Geneva, Switzerland
Serv Hosp Frederic Joliot, CEA, Orsay, France
EPFL, Swiss Fed Inst Technol, Lausanne, Switzerland
Rush Presbyterian St Lukes Med Ctr, Dept Neurol Sci, Chicago, USA

Label: Rascol-2000
Title: A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa
Journal: NEW ENGL J MED, vol. 342, p. 1484-1491, 2000
Citations: 394
Authors: Rascol, O; Brooks, DJ; Korczyn, AD; De Deyn, PP; Clarke, CE; Lang, AE; 056 Study Grp
Addresses:
Univ Hosp, INSERM, Toulouse, France
Hammersmith Hosp, Imperial Coll Sch Med, London, England
Tel Aviv Univ, Sch Med, Ramat Aviv, Israel
Born Bunge Fdn, Gen Hosp Middelheim, Antwerp, Belgium
Univ Antwerp, , Antwerp, Belgium
Univ Birmingham, Dept Neurol, Birmingham, England
Univ Toronto, Dept Med Neurol, Toronto, Canada
Toronto Western Hosp, , Toronto, Canada
Fac Med Toulouse, Serv Pharmacol Med & Clin, Toulouse, France

Label: Olanow-1999
Title: Etiology and pathogenesis of Parkinson's disease
Journal: ANNU REV NEUROSCI, vol. 22, p. 123-144, 1999
Citations: 388
Authors: Olanow, CW; Tatton, WG
Addresses:
Mt Sinai Med Ctr, Dept Neurol, New York, USA

Label: Baron-1996
Title: Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study
Journal: ANN NEUROL, vol. 40, p. 355-366, 1996
Citations: 375
Authors: Baron, MS; Vitek, JL; Bakay, RAE; Green, J; Kaneoke, Y; Hashimoto, T; Turner, RS; Woodard, JL; Cole, SA; McDonald, WM; Delong, MR
Addresses:
EMORY UNIV, DEPT NEUROSURG, SCH MED, ATLANTA, USA
EMORY UNIV, DEPT PSYCHIAT, SCH MED, ATLANTA, USA
EMORY UNIV, DEPT NEUROL, SCH MED, 6000 WMRB, ATLANTA, USA

Label: Forno-1996
Title: Neuropathology of Parkinson's disease
Journal: J NEUROPATH EXP NEUR, vol. 55, p. 259-272, 1996
Citations: 372
Authors: Forno, LS
Addresses:
VA PALO ALTO HLTH CARE SYST, DEPT PATHOL 113, 3801 MIRANDA AVE, PALO ALTO, USA

Label: Singleton-2003
Title: alpha-synuclein locus triplication causes Parkinson's disease
Journal: SCIENCE, vol. 302, p. 841-841, 2003
Citations: 371
Authors: Singleton, AB; Farrer, M; Johnson, J; Singleton, A; Hague, S; Kachergus, J; Hulihan, M; Peuralinna, T; Dutra, A; Nussbaum, R; Lincoln, S; Crawley, A; Hanson, M; Maraganore, D; Adler, C; Cookson, MR; Muenter, M; Baptista, M; Miller, D; Blancato, J; Hardy, J; Gwinn-Hardy, K
Addresses:
NIA, Neurogenet Lab, Bethesda, USA
NINDS, Neurogenet Branch, Bethesda, USA
NHGRI, Genet Dis Res Branch, Bethesda, USA
Mayo Clin, Genet Neurodgenerat Lab, Jacksonville, USA
Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, USA
Mayo Clin, Dept Neurol, Scottsdale, USA
Georgetown Univ, Med Ctr, Washington, USA