Schizophrenia is a chronic and serious brain disorder marked by
hallucinations and delusions. According to the National Institute of
Mental Health, the disease affects approximately one percent of
Americans, generally manifesting in men in their late teens and in
women in their mid-twenties to early thirties. Schizophrenia appears
to afflict both men and women equally, and does not seem to be more
prevalent in any ethnic group. Special Topics has analyzed the
publications on schizophrenia over the past decade and over the past
two years.
The most prevalent theme of the past decade is that of treatment.
Drug trials comparing olanzapine, haloperidol, risperidone,
clozapine, and quetiapine with each other as well as with placebo
dominate the top 20 papers over the past 10 years. Also notable is
the research on schizophrenia genetics, which includes examinations
of neuregulin 1 and COMT Val/Met alleles. MRI findings in
schizophrenic brains, neurocognitive deficits, and diagnostic tools
are also among the top 20 papers on this list.
Over the past two years, the dominant topic appears to have
shifted from drug treatment to schizophrenia genetics. Among the
genetics papers on the list of the top 20 papers published in the
past two years are studies of DISC1, neuregulin 1, BDNF, COMT
Val/Met, PDE4B, and mitochondria-related genes. The effects of drug
treatment on glucose metabolism, the CATIE trial, neurochemical
markers, remission criteria, and social factors of schizophrenia are
also addressed in this list.
Methodology
To construct this database,
papers were extracted based on title-supplied keywords for
Schizophrenia. The keywords used were as follows:
schizophreni*
The baseline time span for this database
is 1997-June 30, 2007 (third bimonthly period of 2007). The resulting database contained
13,989 (10 years)
and 3,876 (2 years) papers; 26,117 authors;
99 countries; 947 journals; and 6,863 institutions.
The baseline time span for this database
is 1997-June 30, 2007 (third bimonthly period of 2007). The resulting database contained
13,989 (10 years)
and 3,876 (2 years) papers; 26,117 authors;
99 countries; 947 journals; and 6,863 institutions.
Rankings
Once the database was in place,
it was used to generate the lists of top 20 papers (two- and ten-year
periods), authors, journals,
institutions, and nations, covering a time span of 1997-June 30, 2007 (third bimonthly, a
ten-year plus six-month period).
The top 20 papers are ranked
according to total cites. Rankings for author, journal, institution,
and country are listed in three ways: according to total cites, total
papers, and total cites/paper. The paper thresholds and corresponding
percentages used to determine
scientist, institution, country, and journal rankings according to
total cites/paper, and total papers respectively are as follows:
| Entity: |
Scientists |
Institutions |
Countries |
Journals |
| Thresholds: |
25 |
73 |
10 |
24 |
| Percentage: |
1% |
1% |
50% |
10% |
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