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TOP PAPERS published in the last
two-year plus two-month period
(first bimonthly; 2005-February 28,
2007)
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 ***Article 1
Total Cites: 223
Article Title: Toll-like receptors in innate immunity
Authors: Takeda, K, Akira, S
Journal: INTERNATIONAL IMMUNOLOGY
Volume: 17
Page: 39096
Year: 2005
Addresses:
· Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita,
Japan
· Japan Sci & Technol Agcy, ERATO, Suita, Japan
· Kyushu Univ, Med Inst Bioregulat, Dept Mol Genet, Higashi
Ku, Fukuoka, Japan
· Osaka Univ, Microbial Dis Res Inst, Dept Host Def, 3-1
Yamada Oka, Suita, Japan
***Article 2
Total Cites: 156
Article Title: Nod2 mutation in Crohn's disease potentiates
NF-kappa B activity and IL-10 processing
Authors: Maeda, S, Hsu, LC, Liu, HJ, Bankston, LA, Iimura,
M, Kagnoff, MF, Eckmann, L, Karin, M
Journal: SCIENCE
Volume: 307
Page: 734-738
Year: 2005
Addresses:
· Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene
Regulat & Signal Transduct, La Jolla, CA, USA
· Univ Calif San Diego, Sch Med, Dept Med, Lab Mucosal
Immunol, La Jolla, CA, USA
· Univ Calif San Diego, Sch Med, Dept Pediat, Lab Mucosal
Immunol, La Jolla, CA, USA
· Burnham Inst, Program Cell Adhes, La Jolla, CA, USA
***Article 3
Total Cites: 132
Article Title: IRF-7 is the master regulator of type-I
interferon-dependent immune responses
Authors: Honda, K, Yanai, H, Negishi, H, Asagiri, M, Sato,
M, Mizutani, T, Shimada, N, Ohba, Y, Takaoka, A, Yoshida, N,
Taniguchi, T
Journal: NATURE
Volume: 434
Page: 772-777
Year: 2005
Addresses:
· Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo,
Japan
· Univ Tokyo, Fac Med, Tokyo, Japan
· Univ Tokyo, Inst Med Sci, Minato Ku, Tokyo, Japan
· JST, PRESTO, Informat & Cell Funct, Kawaguchi, Japan
***Article 4
Total Cites: 123
Article Title: Cell type-specific involvement of RIG-I in
antiviral response
Authors: Kato, H, Sato, S, Yoneyama, M, Yamamoto, M, Uematsu,
S, Matsui, K, Tsujimura, T, Takeda, K, Fujita, T, Takeuchi,
O, Akira, S
Journal: IMMUNITY
Volume: 23
Page: 19-28
Year: 2005
Addresses:
· Osaka Univ, Res Inst Microbial Dis, Dept Host Defense,
Suita, Japan
· ERATO, Japan Sci & Technol Agcy, Suita, Japan
· Tokyo Metropolitan Inst Med Sci, Tokyo Metropolitan Organ
Med REs, Bunkyo Ku, Tokyo, Japan
· Hyogo Med Univ, Dept Pathol, Nishinomiya, Japan
· Kyushu Univ, Med Inst Bioregulat, Dept Mol Genet, Higashi
Ku, Fukuoka, Japan
· Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, 2-2
Yamadaoka, Suita, Japan
***Article 5
Total Cites: 121
Article Title: Pathogen recognition and innate immunity
Authors: Akira, S, Uematsu, S, Takeuchi, O
Journal: CELL
Volume: 124
Page: 783-801
Year: 2006
Addresses:
· Osaka Univ, Res Inst Microbial Dis, Dept Host Defense,
Suita, Japan
· ERATO, Japan Sci & Technol Agcy, Suita, Japan
· Osaka Univ, Res Inst Microbial Dis, Dept Host Defense, 3-1
Yamadaoka, Suita, Japan
***Article 6
Total Cites: 120
Article Title: Sequence-specific potent induction of IFN-alpha
by short interfering RNA in plasmacytoid dendritic cells
through TLR7
Authors: Hornung, V, Guenthner-biller, M, Bourquin, C,
Ablasser, A, Schlee, M, Uematsu, S, Noronha, A, Manoharan,
M, Akira, S, de Fougerolles, A, Endres, S, Hartmann, G
Journal: NAT MED
Volume: 11
Page: 263-270
Year: 2005
Addresses:
· Univ Munich, Dept Internal Med, Div Clin Pharmacol,
Munich, Germany
· GSF, Natl Res Ctr & Environm & Hlth, Inst Clin Mol Biol &
Tumor Genet, Munich, Germany
· Alnylam Pharmaceut Inc, Cambridge, MA, USA
· Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka,
Japan
· Univ Munich, Dept Internal Med, Div Clin Pharmacol,
Ziemssenstr 1, Munich, Germany
***Article 7
Total Cites: 119
Article Title: IPC: Professional type 1 interferon-producing
cells and plasmacytoid dendritic cell precursors
Authors: Liu, YJ
Journal: ANNUAL REVIEW OF IMMUNOLOGY
Volume: 23
Page: 275-306
Year: 2005
Addresses:
· Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston,
TX, USA
· Univ Texas, MD Anderson Canc Ctr, Ctr Canc Immunol Res,
Houston, TX, USA
***Article 8
Total Cites: 110
Article Title: Cardif is an adaptor protein in the RIG-I
antiviral pathway and is targeted by hepatitis C virus
Authors: Meylan, E, Curran, J, Hofmann, K, Moradpour, D,
Binder, M, Bartenschlager, R, Tschopp, R
Journal: NATURE
Volume: 437
Page: 1167-1172
Year: 2005
Addresses:
· Univ Lausanne, Dept Biochem, BIL Biomed Res Ctr, Epalinges,
Switzerland
· Univ Geneva, Fac Med, Dept Microbiol & Mol Med, Geneva,
Switzerland
· MEMOREC Biotec GmbH, Cologne, Germany
· CHU Vaudois, Div Gastroenterol & Hepatol, Lausanne,
Switzerland
· Univ Heidelberg, Dept Mol Virol, Heidelberg, Germany
· Univ Lausanne, Dept Biochem, BIL Biomed Res Ctr, Chemin
Boveresses 155, Epalinges, Switzerland
***Article 9
Total Cites: 101
Article Title: IPS-1, an adaptor triggering RIG-I- and
Mda5-mediated type I interferon induction
Authors: Kawai, T, Takahashi, K, Sato, S, Coban, C, Kumar,
H, Kato, H, Ishii, KJ, Takeuchi, O, Akira, S
Journal: NATURE IMMUNOLOGY
Volume: 6
Page: 981-988
Year: 2005
Addresses:
· Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita,
Japan
· Osaka Univ, Microbial Dis Res Inst, Combined Program
Microbiol & Immunol, 21st Century COE, Suita, Japan
· Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol,
Sakyo Ku, Kyoto, Japan
***Article 10
Total Cites: 94
Article Title: NOD-LRR proteins: Role in host-microbial
interactions and inflammatory disease
Authors: Inohara, N, Chamaillard, M, Mcdonald, C, Nunez, G
Journal: ANNUAL REVIEW OF BIOCHEMISTRY
Volume: 74
Page: 355-383
Year: 2005
Addresses:
· Univ Michigan, Dept Pathol, Ann Arbor, MI, USA
· Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI, USA
***Article 11
Total Cites: 92
Article Title: Immune evasion by hepatitis C virus NS3/4A
protease-mediated cleavage of the Toll-like receptor 3
adaptor protein TRIF
Authors: Li, K, Foy, E, Ferreon, JC, Nakamura, M, Ferreon,
ACM, Ikeda, M, Ray, SC, Gale, M, Lemon, SM
Journal: P NATL ACAD SCI USA
Volume: 102
Page: 2992-2997
Year: 2005
Addresses:
· Univ Texas, Med Branch, Dept Microbiol & Immunol,
Galveston, TX, USA
· Univ Texas, Med Branch, Dept Human Biol Chem & Genet,
Galveston, TX, USA
· Univ Texas, Med Branch, Inst Human Infect & Immun,
Galveston, TX, USA
· Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX, USA
· Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD, USA
· Univ Texas, Med Branch, Dept Microbiol & Immunol, 5-220
Mary Moody No Pavil,301 Univ Blvd, Galveston, TX, USA
***Article 12
Total Cites: 91
Article Title: Spatiotemporal regulation of MyD88-IRF-7
signalling for robust type-I interferon induction
Authors: Honda, K, Ohba, Y, Yanai, H, Negishi, H, Mizutani,
T, Takaoka, A, Taya, C, Taniguchi, T
Journal: NATURE
Volume: 434
Page: 1035-1040
Year: 2005
Addresses:
· Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo,
Japan
· Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo, Japan
· JST, PRESTO, Informat & Cell Funct, Kawaguchi, Japan
· Tokyo Metropolitan Inst Med Sci, Dept Lab Anim Sci, Bunkyo
Ku, Tokyo, Japan
***Article 13
Total Cites: 89
Article Title: VISA is an adapter protein required for
virus-triggered IFN-beta signaling
Authors: Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, ZH, Shu,
HB
Journal: MOLECULAR CELL
Volume: 19
Page: 727-740
Year: 2005
Addresses:
· Natl Jewish Med & Res Ctr, Dept Immunol, Denver, CO, USA
· Peking Univ, Dept Cell Biol & Genet, Beijing, Peoples R
China
· Wuhan Univ, Coll Life Sci, Wuhan, Peoples R China
· Natl Jewish Med & Res Ctr, Dept Immunol, 1400 Jackson St,
Denver, CO, USA
***Article 14
Total Cites: 88
Article Title: Sequence-dependent stimulation of the
mammalian innate immune response by synthetic siRNA
Authors: Judge, AD, Sood, V, Shaw, JR, Fang, D, Mcclintock,
K, Maclachlan, I
Journal: NATURE BIOTECHNOLOGY
Volume: 23
Page: 457-462
Year: 2005
Addresses:
· Protiva Biotherapeut, Burnaby, Canada
· Protiva Biotherapeut, 100-3480 Gilmore Way, Burnaby,
Canada
***Article 15
Total Cites: 88
Article Title: TLR11 activation of dendritic cells by a
protozoan profilin-like protein
Authors: Yarovinsky, F, Zhang, DK, Andersen, JF, Bannenberg,
GL, Serhan, CN, Hayden, MS, Hieny, S, Sutterwala, FS,
Flavell, RA, Ghosh, S, Sher, A
Journal: SCIENCE
Volume: 308
Page: 1626-1629
Year: 2005
Addresses:
· NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda,
MD, USA
· NIAID, Med Entomol Sect, Lab Malaria & Vector Res, NIH,
Bethesda, MD, USA
· Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Mol
Biophys & Biochem, New Haven, CT, USA
· Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT, USA
· Harvard Univ, Brigham & Womens Hosp, Sch Med,Ctr Expt
Therapeut & Reperfus Injury, Dept Anesthesiol Perioperat &
Pain Med, Boston, MA, USA
***Article 16
Total Cites: 86
Article Title: Type I interferons (alpha/beta) in immunity
and autoimmunity
Authors: Theofilopoulos, AN, Baccala, R, Beutler, B, Kono,
DH
Journal: ANNUAL REVIEW OF IMMUNOLOGY
Volume: 23
Page: 307-336
Year: 2005
Addresses:
· Scripps Res Inst, Dept Immunol, La Jolla, CA, USA
· Scripps Res Inst, Dept Immunol, 10666 N Torrey Pines Rd,
La Jolla, CA, USA
***Article 17
Total Cites: 85
Article Title: CD36 is a sensor of diacylglycerides
Authors: Hoebe, K, Georgel, P, Rutschmann, S, Du, X, Mudd,
S, Crozat, K, Sovath, S, Shamel, L, Hartung, T, Zahringer,
U, Beutler, B
Journal: NATURE
Volume: 433
Page: 523-527
Year: 2005
Addresses:
· Scripps Res Inst, Dept Immunol, La Jolla, CA, USA
· EU Joint Res Ctr, ECVAM, Ispra, Italy
· Leibniz Ctr Med & Biosci, Res Ctr Borstel, Borstel,
Germany
· Scripps Res Inst, Dept Immunol, 10666 N Torrey Pines Rd,
La Jolla, CA, USA
***Article 18
Total Cites: 82
Article Title: Inflammatory mediators are insufficient for
full dendritic cell activation and promote expansion of
CD4(+) T cell populations lacking helper function
Authors: Sporri, R, Sousa, CRE
Journal: NATURE IMMUNOLOGY
Volume: 6
Page: 163-170
Year: 2005
Addresses:
· London Res Inst, Immunobiol Lab, Canc Res UK, London,
England
***Article 19
Total Cites: 80
Article Title: Negative regulation of Toll-like
receptor-mediated immune responses
Authors: Liew, FY, Xu, DM, Brint, EK, Oneill, LAJ
Journal: NATURE REVIEWS IMMUNOLOGY
Volume: 5
Page: 446-458
Year: 2005
Addresses:
· Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow,
Scotland
· Univ Dublin Trinity Coll, Dept Biochem, Xoma Ireland,
Dublin, Ireland
***Article 20
Total Cites: 80
Article Title: Human lupus autoantibody-DNA complexes
activate DCs through cooperation of CD32 and TLR9
Authors: Means, TK, Latz, E, Hayashi, F, Murali, MR,
Golenbock, DT, Luster, AD
Journal: JOURNAL OF CLINICAL INVESTIGATION
Volume: 115
Page: 407-417
Year: 2005
Addresses:
· Massachusetts Gen Hosp, Charlestown, MA, USA
· Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis,
Boston, MA, USA
· Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol,
Boston, MA, USA
· Harvard Univ, Sch Med, Boston, MA, USA
· Univ Massachusetts, Sch Med, Dept Med, Worcester, MA, USA
· Massachusetts Gen Hosp, 149 13th St, Charlestown, MA, USA
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