Label: Poltorak-1998
Title: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
Journal: SCIENCE, vol. 282, p. 2085-2088, 1998
Citations: 2424
Authors: Poltorak, A; He, XL; Smirnova, I; Liu, MY; Van Huffel, C; Du, X; Birdwell, D; Alejos, E; Silva, M; Galanos, C; Freudenberg, M; Ricciardi-Castagnoli, P; Layton, B; Beutler, B
Addresses:
Univ Texas, SW Med Ctr, Dallas, USA
Univ Texas, SW Med Ctr, Dallas, USA
CNR, Cellular & Mol Pharmacol Ctr, Milan, Italy
Max Planck Inst Immunbiol, , Freiburg, Germany
Univ Texas, SW Med Ctr, Dallas, USA

Label: Banchereau-2000
Title: Immunobiology of dendritic cells
Journal: ANNU REV IMMUNOL, vol. 18, p. 767-+, 2000
Citations: 1940
Authors: Banchereau, J; Briere, F; Caux, C; Davoust, J; Lebecque, S; Liu, YT; Pulendran, B; Palucka, K
Addresses:
Baylor Inst Immunol Res, , Dallas, USA
Schering Plough, Lab Immunol Res, Dardilly, France
DNAX, Inst Res, Palo Alto, USA

Label: Hemmi-2000
Title: A Toll-like receptor recognizes bacterial DNA
Journal: NATURE, vol. 408, p. 740-745, 2000
Citations: 1712
Authors: Hemmi, H; Takeuchi, O; Kawai, T; Kaisho, T; Sato, S; Sanjo, H; Matsumoto, M; Hoshino, K; Wagner, H; Takeda, K; Akira, S
Addresses:
Osaka Univ, Microbial Dis Res Inst, Osaka, Japan
Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Osaka, Japan
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, Munich, Germany
Osaka Univ, Microbial Dis Res Inst, Osaka, Japan

Label: Takeuchi-1999
Title: Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
Journal: IMMUNITY, vol. 11, p. 443-451, 1999
Citations: 1148
Authors: Takeuchi, O; Hoshino, K; Kawai, T; Sanjo, H; Takada, H; Ogawa, T; Takeda, K; Akira, S
Addresses:
Osaka Univ, Dept Host Def, Suita, Japan
Core Res Evolutional Sci & Technol Japan Sci, , Suita, Japan
Technol Corp, , Suita, Japan
Tohoku Univ, Sch Dent, Sendai, Japan
Asahi Univ, Sch Dent, Gifu, Japan
Osaka Univ, Dept Host Def, Suita, Japan

Label: Janeway-2002
Title: Innate immune recognition
Journal: ANNU REV IMMUNOL, vol. 20, p. 197-216, 2002
Citations: 1147
Authors: Janeway, CA; Medzhitov, R
Addresses:
Yale Univ, Sch Med, New Haven, USA
Yale Univ, Sch Med, New Haven, USA
Yale Univ, Sch Med, New Haven, USA

Label: Alexopoulou-2001
Title: Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3
Journal: NATURE, vol. 413, p. 732-738, 2001
Citations: 1134
Authors: Alexopoulou, L; Holt, AC; Medzhitov, R; Flavell, RA
Addresses:
Immunobiol Sect, , New Haven, USA
Dept Mol Cellular & Dev Biol, , New Haven, USA
Howard Hughes Med Inst, , New Haven, USA
Yale Univ, Sch Med, New Haven, USA

Label: Hoshino-1999
Title: Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
Journal: J IMMUNOL, vol. 162, p. 3749-3752, 1999
Citations: 1111
Authors: Hoshino, K; Takeuchi, O; Kawai, T; Sanjo, H; Ogawa, T; Takeda, Y; Takeda, K; Akira, S
Addresses:
Hyogo Coll Med, Dept Biochem, Nishinomiya, Japan
Int Med Ctr Japan, Inst Res, Tokyo, Japan
Asahi Univ, Sch Dent, Gifu, Japan
Japan Sci & Technol Corp, Core Res Evolutional Sci & Technol, Tokyo, Japan
Hyogo Coll Med, Dept Biochem, Nishinomiya, Japan

Label: Akira-2001
Title: Toll-like receptors: critical proteins linking innate and acquired immunity
Journal: NAT IMMUNOL, vol. 2, p. 675-680, 2001
Citations: 1096
Authors: Akira, S; Takeda, K; Kaisho, T
Addresses:
Osaka Univ, Dept Host Def, Osaka, Japan
Japan Sci & Technol Corp, SORST, Tokyo, Japan

Label: Takeda-2003
Title: Toll-like receptors
Journal: ANNU REV IMMUNOL, vol. 21, p. 335-376, 2003
Citations: 1079
Authors: Takeda, K; Kaisho, T; Akira, S
Addresses:
Osaka Univ, Res Inst Microbial Dis, Suita, Japan
Japan Sci & Technol Corp, Solut Oriented Res Sci & Technol, Suita, Japan
RIKEN, Res Ctr Allergy & Immunol, Suita, Japan
Osaka Univ, Res Inst Microbial Dis, Suita, Japan

Label: Aderem-2000
Title: Toll-like receptors in the induction of the innate immune response
Journal: NATURE, vol. 406, p. 782-787, 2000
Citations: 956
Authors: Aderem, A; Ulevitch, RJ
Addresses:
Univ Washington, Dept Immunol, Seattle, USA
Scripps Res Inst, Dept Immunol, La Jolla, USA

Label: Kyriakis-2001
Title: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
Journal: PHYSIOL REV, vol. 81, p. 807-869, 2001
Citations: 831
Authors: Kyriakis, JM; Avruch, J
Addresses:
Massachusetts Gen Hosp E, Diabet Res Lab, Charlestown, USA
Massachusetts Gen Hosp, Dept Mol Biol, Boston, USA
Harvard Univ, Sch Med, Boston, USA
Massachusetts Gen Hosp E, Diabet Res Lab, Charlestown, USA

Label: Hayashi-2001
Title: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Journal: NATURE, vol. 410, p. 1099-1103, 2001
Citations: 775
Authors: Hayashi, F; Smith, KD; Ozinsky, A; Hawn, TR; Yi, EC; Goodlett, DR; Eng, JK; Akira, S; Underhill, DM; Aderem, A
Addresses:
Inst Syst Biol, , Seattle, USA
Univ Washington, Dept Immunol, Seattle, USA
Univ Washington, Dept Pathol, Seattle, USA
Univ Washington, Div Allergy & Infect Dis, Seattle, USA
Osaka Univ, Microbial Dis Res Inst, Suita, Japan
Inst Syst Biol, 4225 Roosevelt Way NE,Suite 200, Seattle, USA

Label: Akira-2004
Title: Toll-like receptor signalling
Journal: NAT REV IMMUNOL, vol. 4, p. 499-511, 2004
Citations: 765
Authors: Akira, S; Takeda, K
Addresses:
Osaka Univ, Dept Host Def, Osaka, Japan
Japan Sci & Technol Agcy, ERATO, Osaka, Japan
Kyushu Univ, Dept Mol Genet, Fukuoka, Japan
Osaka Univ, Dept Host Def, Osaka, Japan

Label: Qureshi-1999
Title: Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4)
Journal: J EXP MED, vol. 189, p. 615-625, 1999
Citations: 757
Authors: Qureshi, ST; Lariviere, L; Leveque, G; Clermont, S; Moore, KJ; Gros, P; Malo, D
Addresses:
McGill Univ, Dept Med, Montreal, Canada
McGill Univ, Dept Biochem, Montreal, Canada
McGill Univ, Dept Human Genet, Montreal, Canada
Montreal Gen Hosp, Ctr Study Host Resistance, Montreal, Canada
Millennium Pharmaceut Inc, , Cambridge, USA
Montreal Gen Hosp, Ctr Study Host Resistance, Montreal, Canada

Label: Yang-1998
Title: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Journal: NATURE, vol. 395, p. 284-288, 1998
Citations: 752
Authors: Yang, RB; Mark, MR; Gray, A; Huang, A; Xie, MH; Zhang, M; Goddard, A; Wood, WI; Gurney, AL; Godowski, PJ
Addresses:
Genentech Inc, Dept Mol Biol, S San Francisco, USA

Label: Krieg-2002
Title: CpG motifs in bacterial DNA and their immune effects
Journal: ANNU REV IMMUNOL, vol. 20, p. 709-760, 2002
Citations: 717
Authors: Krieg, AM
Addresses:
Dept Vet Affairs Med Ctr, , Iowa City, USA
Univ Iowa, Coll Med, Iowa City, USA
Coley Pharmaceut Grp, , Wellesley, USA

Label: Brightbill-1999
Title: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
Journal: SCIENCE, vol. 285, p. 732-736, 1999
Citations: 702
Authors: Brightbill, HD; Libraty, DH; Krutzik, SR; Yang, RB; Belisle, JT; Bleharski, JR; Maitland, M; Norgard, MV; Plevy, SE; Smale, ST; Brennan, PJ; Bloom, BR; Godowski, PJ; Modlin, RL
Addresses:
Univ Calif Los Angeles, Sch Med, Los Angeles, USA
Univ Calif Los Angeles, Sch Med, Los Angeles, USA
Univ Calif Los Angeles, Sch Med, Los Angeles, USA
Univ Calif Los Angeles, Sch Med, Los Angeles, USA
Univ Calif Los Angeles, Sch Med, Los Angeles, USA
Genentech Inc, , S San Francisco, USA
Colorado State Univ, Dept Microbiol, Ft Collins, USA
Yeshiva Univ Albert Einstein Coll Med, Howard Hughes Med Inst, Bronx, USA
Univ Texas, SW Med Ctr, Dallas, USA
CUNY Mt Sinai Sch Med, Ctr Immunol, New York, USA
Harvard Univ, Sch Publ Hlth, Boston, USA

Label: Rock-1998
Title: A family of human receptors structurally related to Drosophila Toll
Journal: P NATL ACAD SCI USA, vol. 95, p. 588-593, 1998
Citations: 697
Authors: Rock, FL; Hardiman, G; Timans, JC; Kastelein, RA; Bazan, JF
Addresses:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Palo Alto, USA
DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Palo Alto, USA

Label: Dangl-2001
Title: Plant pathogens and integrated defence responses to infection
Journal: NATURE, vol. 411, p. 826-833, 2001
Citations: 685
Authors: Dangl, JL; Jones, JDG
Addresses:
Univ N Carolina, Dept Biol, Chapel Hill, USA
Univ N Carolina, Curriculum Genet, Chapel Hill, USA
John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich, England
Univ N Carolina, Dept Biol, Chapel Hill, USA

Label: Shimazu-1999
Title: MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
Journal: J EXP MED, vol. 189, p. 1777-1782, 1999
Citations: 677
Authors: Shimazu, R; Akashi, S; Ogata, H; Nagai, Y; Fukudome, K; Miyake, K; Kimoto, M
Addresses:
Saga Med Sch, Dept Immunol, Saga, Japan