Label: Alexopoulou-2001
Title: Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3
Journal: NATURE, 413 (6857): 732-738 OCT 18 2001
Citations: 1134
Authors: Alexopoulou, L;Holt, AC;Medzhitov, R;Flavell, RA
Addresses:
Immunobiol Sect, New Haven, CT 06520 USA
Immunobiol Sect, New Haven, CT 06520 USA
Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
Howard Hughes Med Inst, New Haven, CT 06520 USA
Yale Univ, Sch Med, New Haven, CT 06520 USA
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Label: Hayashi-2001
Title: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Journal: NATURE, 410 (6832): 1099-1103 APR 26 2001
Citations: 775
Authors: Hayashi, F;Smith, KD;Ozinsky, A;Hawn, TR;Yi, EC;Goodlett, DR;Eng, JK;Akira, S;Underhill, DM;Aderem, A
Addresses:
Inst Syst Biol, 4225 Roosevelt Way NE,Suite 200, Seattle, WA 98195 USA
Inst Syst Biol, Seattle, WA 98195 USA
Univ Washington, Dept Immunol, Seattle, WA 98195 USA
Univ Washington, Dept Pathol, Seattle, WA 98195 USA
Univ Washington, Div Allergy & Infect Dis, Seattle, WA 98195 USA
Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan
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Label: Heil-2004
Title: Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Journal: SCIENCE, 303 (5663): 1526-1529 MAR 5 2004
Citations: 500
Authors: Heil, F;Hemmi, H;Hochrein, H;Ampenberger, F;Kirschning, C;Akira, S;Lipford, G;Wagner, H;Bauer, S
Addresses:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, Trogerstr 9, D-81675 Munich, Germany
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany
Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan
Japan Sci & Technol Corp, ERATO, Osaka 5650047, Japan
Coley Pharmaceut Grp Inc, Wellesley, MA 02481 USA
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Label: Hemmi-2002
Title: Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
Journal: NAT IMMUNOL, 3 (2): 196-200 FEB 2002
Citations: 476
Authors: Hemmi, H;Kaisho, T;Takeuchi, O;Sato, S;Sanjo, H;Hoshino, K;Horiuchi, T;Tomizawa, H;Takeda, K;Akira, S
Addresses:
Osaka Univ, Microbial Dis Res Inst, Dept Host Def, 3-1 Yamada Oka, Suita, Osaka 5650871, Japan
Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan
Japan Sci & Technol Corp, Solut Oriented Res Sci & Technol, Suita, Osaka 5650871, Japan
Japan Energy Corp, Pharmaceut & Biotechnol Lab, Toda, Saitama 3358502, Japan
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Label: Diebold-2004
Title: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Journal: SCIENCE, 303 (5663): 1529-1531 MAR 5 2004
Citations: 466
Authors: Diebold, SS;Kaisho, T;Hemmi, H;Akira, S;Sousa, CRE
Addresses:
London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England
London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England
Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan
RIKEN, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
Japan Sci & Technol Corp, ERATO, Akira Innate Immun Project, Suita, Osaka 5650871, Japan
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Label: Gewirtz-2001
Title: Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
Journal: J IMMUNOL, 167 (4): 1882-1885 AUG 15 2001
Citations: 301
Authors: Gewirtz, AT;Navas, TA;Lyons, S;Godowski, PJ;Madara, JL
Addresses:
Emory Univ, Dept Pathol & Lab Med, Epithelial Pathobiol Div, Atlanta, GA 30322 USA
Emory Univ, Dept Pathol & Lab Med, Epithelial Pathobiol Div, Atlanta, GA 30322 USA
Genentech Inc, Dept Mol Biol, S San Francisco, CA 94080 USA
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Label: Lund-2004
Title: Recognition of single-stranded RNA viruses by Toll-like receptor 7
Journal: PROC NAT ACAD SCI USA, 101 (15): 5598-5603 APR 13 2004
Citations: 257
Authors: Lund, JM;Alexopoulou, L;Sato, A;Karow, M;Adams, NC;Gale, NW;Iwasaki, A;Flavell, RA
Addresses:
Yale Univ, Sch Med, Immunobiol Sect, 333 Cedar St, New Haven, CT 06520 USA
Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA
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Label: Lund-2003
Title: Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells
Journal: J EXP MED, 198 (3): 513-520 AUG 4 2003
Citations: 237
Authors: Lund, J;Sato, A;Akira, S;Medzhitov, R;Iwasaki, A
Addresses:
Dept Epidemiol & Publ Hlth, 60 Coll St,LEPH 716, New Haven, CT 06510 USA
Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA
Osaka Univ, SORST, Japan Sci & Technol Corp, Microbial Dis Res Inst,Dept Host Def, Suita, Osaka 5650871, Japan
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Label: Tabeta-2004
Title: Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
Journal: PROC NAT ACAD SCI USA, 101 (10): 3516-3521 MAR 9 2004
Citations: 175
Authors: Tabeta, K;Georgel, P;Janssen, E;Du, X;Hoebe, K;Crozat, K;Mudd, S;Shamel, L;Sovath, S;Goode, J;Alexopoulou, L;Flavell, RA;Beutler, B
Addresses:
Yale Univ, Immunobiol Sect, New Haven, CT 06520 USA
Yale Univ, Immunobiol Sect, New Haven, CT 06520 USA
Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
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Label: Gewirtz-2001
Title: Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response
Journal: J CLIN INVEST, 107 (1): 99-109 JAN 2001
Citations: 148
Authors: Gewirtz, AT;Simon, PO;Schmitt, CK;Taylor, LJ;Hagedorn, CH;O'Brien, AD;Neish, AS;Madara, JL
Addresses:
Emory Univ, Sch Med, Dept Pathol, Epithelial Pathobiol Div, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Dept Pathol, Epithelial Pathobiol Div, Atlanta, GA 30322 USA
Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD USA
Emory Univ, Sch Med, Dept Med, Digest Dis Unit, Atlanta, GA USA
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Label: Krug-2004
Title: Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
Journal: BLOOD, 103 (4): 1433-1437 FEB 15 2004
Citations: 140
Authors: Krug, A;Luker, GD;Barchet, W;Leib, DA;Akira, S;Colonna, M
Addresses:
Washington Univ, Sch Med, Dept Pathol & Immunol, Mol Imaging Ctr,Mallinckrodt Inst Radiol, Box 8118,660 S Euclid Ave, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol & Immunol, Mol Imaging Ctr,Mallinckrodt Inst Radiol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 565, Japan
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Label: Compton-2003
Title: Human cytomegalovirus activates inflammatory cytokine responses via CD14 and toll-like receptor 2
Journal: J VIROL, 77 (8): 4588-4596 APR 2003
Citations: 131
Authors: Compton, T;Kurt-Jones, EA;Boehme, KW;Belko, J;Latz, E;Golenbock, DT;Finberg, RW
Addresses:
Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA
Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
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Label: Heil-2003
Title: The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
Journal: EUR J IMMUNOL, 33 (11): 2987-2997 NOV 2003
Citations: 123
Authors: Heil, F;Ahmad-Nejad, P;Hemmi, H;Hochrein, H;Ampenberger, F;Gellert, T;Dietrich, H;Lipford, G;Takeda, K;Akira, S;Wagner, H;Bauer, S
Addresses:
Inst Med Microbiol Hyg & Immunol, Trogerstr 9, D-81675 Munich, Germany
Inst Med Microbiol Hyg & Immunol, D-81675 Munich, Germany
Univ Clin Mannheim, Inst Clin Chem, Mannheim, Germany
Osaka Univ, Dept Host Def, Res Inst Microbial Dis, Osaka, Japan
Coley Pharmaceut GmbH, Langenfeld, Germany
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Label: Krug-2004
Title: TL-139-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
Journal: IMMUNITY, 21 (1): 107-119 JUL 2004
Citations: 114
Authors: Krug, A;French, AR;Barchet, W;Fischer, JAA;Dzionek, A;Pingel, JT;Orihuela, MM;Akira, S;Yokoyama, WM;Colonna, M
Addresses:
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA
Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka, Japan
Miltenyi Bioec, Bergisch Gladbach, Germany
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Label: Bieback-2002
Title: Hemagglutinin protein of wild-type measles virus activates Toll-like receptor 2 signaling
Journal: J VIROL, 76 (17): 8729-8736 SEP 2002
Citations: 106
Authors: Bieback, K;Lien, E;Klagge, IM;Avota, E;Schneider-Schaulies, J;Duprex, WP;Wagner, H;Kirschning, CJ;ter Meulen, V;Schneider-Schaulies, S
Addresses:
Univ Wurzburg, Inst Virol & Immunobiol, Versbacher Str 7, D-97078 Wurzburg, Germany
Univ Wurzburg, Inst Virol & Immunobiol, D-97078 Wurzburg, Germany
Tech Univ Munich, Inst Med Microbiol & Hyg, Munich, Germany
Univ Massachusetts, Sch Med, Worcester, MA 01605 USA
Queens Univ Belfast, Sch Biochem, Belfast BT7 9BL, Antrim, North Ireland
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Label: Wang-2004
Title: Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
Journal: NATURE MED, 10 (12): 1366-1373 DEC 2004
Citations: 95
Authors: Wang, T;Town, T;Alexopoulou, L;Anderson, JF;Fikrig, E;Flavell, RA
Addresses:
Yale Univ, Sch Med, Dept Internal Med, Rheumatol Sect, 300 Cedar St, New Haven, CT 06520 USA
Yale Univ, Sch Med, Dept Internal Med, Rheumatol Sect, New Haven, CT 06520 USA
Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
Connecticut Agr Expt Stn, Dept Entomol, New Haven, CT 06504 USA
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Label: Kurt-Jones-2004
Title: Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis
Journal: PROC NAT ACAD SCI USA, 101 (5): 1315-1320 FEB 3 2004
Citations: 87
Authors: Kurt-Jones, EA;Chan, M;Zhou, SH;Wang, J;Reed, G;Bronson, R;Arnold, MM;Knipe, DM;Finberg, RW
Addresses:
Univ Massachusetts, Med Ctr, Dept Med, 364 Plantat St,Lazare Res Bldg, Worcester, MA 01605 USA
Univ Massachusetts, Med Ctr, Dept Med, Worcester, MA 01605 USA
Harvard Univ, Sch Med, Robent Histopathol Core, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
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Label: Edelmann-2004
Title: Does Toll-like receptor 3 play a biological role in virus infections?
Journal: VIROLOGY, 322 (2): 231-238 MAY 1 2004
Citations: 82
Authors: Edelmann, KH;Richardson-Burns, S;Alexopoulou, L;Tyler, KL;Flavell, RA;Oldstone, MBA
Addresses:
Scripps Res Inst, Dept Neuropharmacol, Div Virol, 10550 N Torrey Pines Rd,IMM 6, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Neuropharmacol, Div Virol, La Jolla, CA 92037 USA
Univ Colorado, Hlth Sci Ctr, Program Neurosci, Denver, CO 80262 USA
Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Internal Med, New Haven, CT 06520 USA
Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA
Univ Colorado, Hlth Sci Ctr, Dept Microbiol & Immunol, Denver, CO 80262 USA
Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80262 USA
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